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. 2023 Nov 27;12(23):7342.
doi: 10.3390/jcm12237342.

Articular Cartilage Reconstruction with Hyaluronate-Based Scaffold Significantly Decreases Pain and Improves Patient's Functioning

Jarosław Gryglewicz  1 , Monika Chaszczewska-Markowska  1 , Mateusz Dorochowicz  1 , Jerzy Drożdż  1 , Szymon Łukasz Dragan  1
Affiliations

Articular Cartilage Reconstruction with Hyaluronate-Based Scaffold Significantly Decreases Pain and Improves Patient's Functioning

Jarosław Gryglewicz et al. J Clin Med. .

Abstract

Articular cartilage lesions negatively affect patients' well-being, causing severe pain and significantly limiting functioning. The purpose of this study was to evaluate the effectiveness of a one-stage reconstruction, performed arthroscopically using a hyaluronate-based scaffold. Pain reduction and functional improvement were assessed. The study also evaluated if postoperative vitamin D supplementation and rehabilitation protocol impact obtained outcomes. A group of 29 patients was included in a retrospective study. All the participants underwent arthroscopic reconstruction of osteochondral lesions using hyaluronate-based scaffolds. The study group used standard questionnaires to self-assess their condition before surgery and at the time of completion. Despite the aforementioned, all the participants fulfilled two original questionnaires on postoperative rehabilitation and vitamin D supplementation. Significant pain reduction (mean NRS 1.83 vs. 7.21, p < 0.0001) and functional improvement (mean Lysholm score 82.38 vs. 40.38, p < 0.0001; mean OKS 40.2 vs. 23.1, p < 0.0001) were found. No differences in pain reduction and functional improvement were seen between genders. The impact of post-operative rehabilitation and vitamin D supplementation on clinical outcomes was found to be statistically nonsignificant. The results obtained in this study clearly confirm the effectiveness of osteochondral reconstruction using hyaluronate-based scaffolds. The outcomes were equally favorable, regardless of postoperative rehabilitation and vitamin D supplementation.

Keywords: cartilage; hyalofast; lesion; osteochondral; scaffold; vitamin D.

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Conflict of interest statement

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Pain reduction showed with Numerical Rating Scale (NRS) score after microfractures and cartilage reconstruction using a hyaluronate−based membrane as a scaffold (p < 0.0001). The mean evaluation time was 23.9 months after surgery (min-max 18.00−27.00 months, SD 1.84).
Figure 2
Figure 2
Improvement in patients’ functioning with OKS questionnaire after microfractures and cartilage reconstruction using a hyaluronate−based membrane as a scaffold (p < 0.0001). The mean evaluation time was 23.9 months after surgery (min-max 18.00–27.00 months, SD 1.84).
Figure 3
Figure 3
Improvement in patients’ functioning assessed using the Lysholm Knee Scoring Scale after microfractures and cartilage reconstruction using a hyaluronate−based membrane as a scaffold (p < 0.0001). The mean evaluation time was 23.9 months after surgery (min-max 18.00–27.00 months, SD 1.84).
Figure 4
Figure 4
Described procedure. Cartilage lesion inspection (a); debridement and measurement (b); microfractures (c); implantation of scaffold–dry arthroscopy (d); scaffold augmentation with tissue glue (e).
See this image and copyright information in PMC

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