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Review
. 2023 Nov 30;12(23):7451.
doi: 10.3390/jcm12237451.

A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure

Nazli Begum Ozturk  1 , Emre Herdan  2 , Fuat H Saner  3   4 , Ahmet Gurakar  2
Affiliations
Review

A Comprehensive Review of the Diagnosis and Management of Acute Liver Failure

Nazli Begum Ozturk et al. J Clin Med. .

Abstract

Acute liver failure (ALF) is a rare and specific form of severe hepatic dysfunction characterized by coagulopathy and hepatic encephalopathy in a patient with no known liver disease. ALF carries a high morbidity and mortality. Careful attention should be given to hemodynamics and metabolic parameters along with the active surveillance of infections. Timely transfer and supportive management are important in an intensive care unit in a liver transplant center. Identifying patients who will and will not improve with medical management and may need emergent liver transplantation is critical. In this review, we provide a comprehensive update on the etiology, diagnosis, and management of ALF.

Keywords: acetaminophen; fulminant hepatitis; hepatic encephalopathy; intensive care; liver disease.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Clinical manifestations of acute liver failure.
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