Larvicidal and Adulticidal Activity of Essential Oils from Four Cuban Plants against Three Mosquito Vector Species

Jesús García-Díaz^{1

2}, Raimundo Nonato Picanço Souto³, Julio César Escalona-Arranz^{2

4}, Ricardo Marcelo Dos Anjos Ferreira³, Tiago Silva Da Costa^{5

6}, Rosalia González-Fernández⁷, Yamile Heredia-Díaz², Idelsy Chil-Núñez^{2

3}, Jorge de la Vega⁷, Lianet Monzote^{8

9}, Margareth Maria de Carvalho Queiroz^{10

11}, William N Setzer^{9

12

13}

Affiliations

¹ Department of Basic-Biomedical Sciences, Faculty of Nursing-Health Technology, University of Medical Sciences, Carretera del Caney Km 2 1/2, Santiago de Cuba 90100, Cuba.
² Pharmacy Department, Natural and Exacts Sciences Faculty, Oriente University, Avenida Patricio Lumumba s/n, Santiago de Cuba 90500, Cuba.
³ Laboratory of Arthropoda, Department of Biology and Health Sciences, Universidade Federal do Amapá, Rodovia Jucelino Kubitschek, Km 02, Macapá 68902-280, AP, Brazil.
⁴ Department of Pharmaceutical Sciences, Faculty of Sciences, Universidad Católica del Norte, Angamos, Antofagasta 0610, Chile.
⁵ Laboratório de Arthropoda, Universidade Federal do Amapá, Campus Universitário Marco Zero do Equador, Rodovia Juscelino Kubitschek de Oliveira, Km 02, Bairro Zerão, Macapá 68902-280, AP, Brazil.
⁶ Programa de Pós-Graduação em Biodiversidade Tropical (PPGBIO), Universidade Federal do Amapá (UNIFAP), Macapá 68903-419, AP, Brazil.
⁷ Toxicology and Biomedicine Centre (TOXIMED), University of Medical Science, Autopista Nacional Km 1½ s/n, Santiago de Cuba 90400, Cuba.
⁸ Department of Parasitology, Institute of Tropical Medicine "Pedro Kourí", Apartado Postal No. 601, Marianao 13, La Habana 10400, Cuba.
⁹ Research Network Natural Products against Neglected Diseases (ResNetNPND), 48149 Münster, Germany.
¹⁰ Laboratory of Medical and Forensic Entomology, Instituto Oswaldo Cruz, IOC/FIOCRUZ, Rio de Janeiro 21040-360, RJ, Brazil.
¹¹ Programa de Pós-Graduação-Mestrado Profissional em Ciências Ambientais, Universidade de Vassouras-FUSVE, Av. Expedicionário Oswaldo de Almeida Ramos, 280, Vassouras 27700-000, RJ, Brazil.
¹² Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA.
¹³ Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.

PMID: 38068644
PMCID: PMC10708165
DOI: 10.3390/plants12234009

Larvicidal and Adulticidal Activity of Essential Oils from Four Cuban Plants against Three Mosquito Vector Species

Jesús García-Díaz et al. Plants (Basel). 2023.

. 2023 Nov 29;12(23):4009.

doi: 10.3390/plants12234009.

Authors

Affiliations

¹ Department of Basic-Biomedical Sciences, Faculty of Nursing-Health Technology, University of Medical Sciences, Carretera del Caney Km 2 1/2, Santiago de Cuba 90100, Cuba.
² Pharmacy Department, Natural and Exacts Sciences Faculty, Oriente University, Avenida Patricio Lumumba s/n, Santiago de Cuba 90500, Cuba.
³ Laboratory of Arthropoda, Department of Biology and Health Sciences, Universidade Federal do Amapá, Rodovia Jucelino Kubitschek, Km 02, Macapá 68902-280, AP, Brazil.
⁴ Department of Pharmaceutical Sciences, Faculty of Sciences, Universidad Católica del Norte, Angamos, Antofagasta 0610, Chile.
⁵ Laboratório de Arthropoda, Universidade Federal do Amapá, Campus Universitário Marco Zero do Equador, Rodovia Juscelino Kubitschek de Oliveira, Km 02, Bairro Zerão, Macapá 68902-280, AP, Brazil.
⁶ Programa de Pós-Graduação em Biodiversidade Tropical (PPGBIO), Universidade Federal do Amapá (UNIFAP), Macapá 68903-419, AP, Brazil.
⁷ Toxicology and Biomedicine Centre (TOXIMED), University of Medical Science, Autopista Nacional Km 1½ s/n, Santiago de Cuba 90400, Cuba.
⁸ Department of Parasitology, Institute of Tropical Medicine "Pedro Kourí", Apartado Postal No. 601, Marianao 13, La Habana 10400, Cuba.
⁹ Research Network Natural Products against Neglected Diseases (ResNetNPND), 48149 Münster, Germany.
¹⁰ Laboratory of Medical and Forensic Entomology, Instituto Oswaldo Cruz, IOC/FIOCRUZ, Rio de Janeiro 21040-360, RJ, Brazil.
¹¹ Programa de Pós-Graduação-Mestrado Profissional em Ciências Ambientais, Universidade de Vassouras-FUSVE, Av. Expedicionário Oswaldo de Almeida Ramos, 280, Vassouras 27700-000, RJ, Brazil.
¹² Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA.
¹³ Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.

PMID: 38068644
PMCID: PMC10708165
DOI: 10.3390/plants12234009

Abstract

Mosquitoes are one of the main vectors of many important diseases and their degree of resistance to chemical insecticides has increased. Nowadays, it has become crucial to identify novel plant larvicides with an eco-friendly impact. The components of essential oils from Croton linearis Jacq. (EO-Cl), Lantana involucrata L. (EO-Li), Ocimum sanctum var. cubensis M. Gómez. (EO-Os), and Zanthoxylum pistaciifolium Griseb. (syn. Zanthoxylum flavum subsp. pistaciifolium (Griseb.) Reynel (EO-Zp) were determined using gas chromatography-mass spectrometry (GC-MS) analysis. Larvicidal and adulticidal bioassays against Aedes aegypti, Anopheles albitarsis and Culex quinquefasciatus, were performed according to the World Health Organization standard methods. A high diversity of compounds was identified in the four oils, with a total of 152 compounds (33-70 components). EO-Cl, EO-Li, and EO-Os were classified as active against both insect forms, larvae and adults. Lantana involucrata showed the best results, with LC₅₀ values from 33.8 to 41.7 mg/L. In most of the cases, it was not possible to associate the main compounds with the measured activity, supporting the hypothesis about probable synergistic interactions among major and minor compounds. The results indicate EO-Cl, EO-Os, and EO-Li as good eco-friendly insecticides with potential.

Keywords: Croton linearis; Lantana involucrata; Ocimum sanctum var. cubensis; Zanthoxylum pistaciifolium; adulticidal; essential oil; larvicidal.

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Conflict of interest statement

The authors declare no conflict of interest.

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Larvicidal and Adulticidal Activity of Essential Oils from Four Cuban Plants against Three Mosquito Vector Species

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Larvicidal and Adulticidal Activity of Essential Oils from Four Cuban Plants against Three Mosquito Vector Species

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