Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Dec 3;15(23):5005.
doi: 10.3390/nu15235005.

The Beneficial Effects of Dietary Interventions on Gut Microbiota-An Up-to-Date Critical Review and Future Perspectives

Affiliations
Review

The Beneficial Effects of Dietary Interventions on Gut Microbiota-An Up-to-Date Critical Review and Future Perspectives

Carmen Purdel et al. Nutrients. .

Abstract

Different dietary interventions, especially intermittent fasting, are widely used and promoted by physicians; these regimens have been studied lately for their impact on the gut microbiota composition/function and, consequently, on the general physiopathological processes of the host. Studies are showing that dietary components modulate the microbiota, and, at the same time, the host metabolism is deeply influenced by the different products resulting from nutrient transformation in the microbiota compartment. This reciprocal relationship can potentially influence even drug metabolism for chronic drug regimens, significantly impacting human health/disease. Recently, the influence of various dietary restrictions on the gut microbiota and the differences between the effects were investigated. In this review, we explored the current knowledge of different dietary restrictions on animal and human gut microbiota and the impact of these changes on human health.

Keywords: caloric restriction; dietary intervention; fasting; gut microbiota; interaction.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Potential beneficial effects of dietary interventions on the gut as the results of microbiota changes include TRF—time-restricted fasting; CR—caloric restriction; and ADF—alternate-day fasting.

References

    1. Yassour M., Vatanen T., Siljander H., Hamalainen A.M., Harkonen T., Ryhanen S.J., Franzosa E.A., Vlamakis H., Huttenhower C., Gevers D., et al. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability. Sci. Transl. Med. 2016;8:343ra381. doi: 10.1126/scitranslmed.aad0917. - DOI - PMC - PubMed
    1. Spor A., Koren O., Ley R. Unravelling the effects of the environment and host genotype on the gut microbiome. Nat. Rev. Microbiol. 2011;9:279–290. doi: 10.1038/nrmicro2540. - DOI - PubMed
    1. Hill C.J., Lynch D.B., Murphy K., Ulaszewska M., Jeffery I.B., O’Shea C.A., Watkins C., Dempsey E., Mattivi F., Tuohy K., et al. Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort. Microbiome. 2017;5:4. doi: 10.1186/s40168-016-0213-y. - DOI - PMC - PubMed
    1. Arboleya S., Sanchez B., Milani C., Duranti S., Solis G., Fernandez N., de los Reyes-Gavilan C.G., Ventura M., Margolles A., Gueimonde M. Intestinal microbiota development in preterm neonates and effect of perinatal antibiotics. J. Pediatr. 2015;166:538–544. doi: 10.1016/j.jpeds.2014.09.041. - DOI - PubMed
    1. Ottman N., Smidt H., de Vos W.M., Belzer C. The function of our microbiota: Who is out there and what do they do? Front. Cell. Infect. Microbiol. 2012;2:104. doi: 10.3389/fcimb.2012.00104. - DOI - PMC - PubMed

LinkOut - more resources