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Editorial
. 2024 Feb 8;47(2):zsad309.
doi: 10.1093/sleep/zsad309.

Modeling Drosophila sleep: fly in the sky?

Anne C Skeldon  1   2 , Derk-Jan Dijk  2   3
Affiliations
Editorial

Modeling Drosophila sleep: fly in the sky?

Anne C Skeldon et al. Sleep. .
No abstract available

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Figures

Figure 1.
Figure 1.
Entangled sleep and circadian rhythms in the two-process model: variation in sleep–wake phenotypes may be explained by either modifying homeostatic or circadian parameters. Here are shown sleep–wake patterns for different assumptions on which parameters vary with circadian period. Left-hand panels are for changes in the homeostatic time constants based on the trend line in Abhilash and Shafer [23] Figure 5 panels D and E (although we note that to get the impressive fit shown in Figure 5C they used individually fitted values for both the decay and buildup time constants including the large jump in homeostatic buildup constant between the circadian period of 15 and 20 hours). Right-hand panels keep homeostatic time constants fixed and vary “circadian” parameters. In each case, the two-process model is shown along with two raster plots, one based on the duration of the circadian day (left), one based on the 24-hour day (right). Like Abhilash and Shafer, all simulations use the scaled two-process model which sets the upper and lower asymptotes to 1 and 0, respectively. All other parameters are written in the figure, where Xs and Xw are the time constants for homeostatic decay during sleep and buildup during wake, respectively, Hp and Hm are the mean levels of the upper and lower thresholds and a is the circadian amplitude.
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References

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