Acute NETosis from organophosphate poisoning

Bingwen Eugene Fan^{1

2

3

4}, Guo Feng Abel Teo¹, Kian Guan Eric Lim⁵, Shiun Woei Wong⁶, Yin Wen Lai⁷, Ponnudurai Kuperan^{1

2

3

4}, Siu Ling Wong^{3

8}

Affiliations

¹ Department of Haematology, Tan Tock Seng Hospital, Singapore.
² Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore.
³ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
⁴ Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
⁵ Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore.
⁶ Department of Cardiology, Tan Tock Seng Hospital, Singapore.
⁷ Accident and Emergency, Tan Tock Seng Hospital, Singapore.
⁸ Tan Tock Seng Hospital, Singapore.

Case Reports

Bingwen Eugene Fan et al. Am J Hematol. 2024 Dec.

. 2024 Dec;99(12):2386-2387.

doi: 10.1002/ajh.27173. Epub 2023 Dec 8.

Bingwen Eugene Fan^{1

2

3

4}, Guo Feng Abel Teo¹, Kian Guan Eric Lim⁵, Shiun Woei Wong⁶, Yin Wen Lai⁷, Ponnudurai Kuperan^{1

2

3

4}, Siu Ling Wong^{3

8}

¹ Department of Haematology, Tan Tock Seng Hospital, Singapore.
² Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore.
³ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
⁴ Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
⁵ Department of Laboratory Medicine, Tan Tock Seng Hospital, Singapore.
⁶ Department of Cardiology, Tan Tock Seng Hospital, Singapore.
⁷ Accident and Emergency, Tan Tock Seng Hospital, Singapore.
⁸ Tan Tock Seng Hospital, Singapore.

No abstract available

References

1. Rathouz MM, Vijayaraghavan S, Berg DK. Acetylcholine differentially affects intracellular calcium via nicotinic and muscarinic receptors on the same population of neurons. J Biol Chem. 1995;270(24):14366‐14375. doi:10.1074/jbc.270.24.14366
1. Costas‐Ferreira C, Faro LRF. Systematic review of calcium channels and intracellular calcium signaling: relevance to pesticide neurotoxicity. Int J Mol Sci. 2021;22(24):13376. doi:10.3390/ijms222413376
1. Vorobjeva NV, Chernyak BV. NETosis: molecular mechanisms, role in physiology and pathology. Biochemistry (Mosc). 2020;85(10):1178‐1190. doi:10.1134/S0006297920100065
1. Wong SL, Demers M, Martinod K, et al. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med. 2015;21(7):815‐819. doi:10.1038/nm.3887
1. Sorvillo N, Cherpokova D, Martinod K, Wagner DD. Extracellular DNA NET‐works with dire consequences for health. Circ Res. 2019;125(4):470‐488. doi:10.1161/CIRCRESAHA.119.314581