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Review
. 2023 Dec;164(6):1454-1461.
doi: 10.1016/j.chest.2023.09.009.

Identification and Management of Acute Neuromuscular Respiratory Failure in the ICU

Jennifer T W Krall  1 , Akash Chakravartty  2 , James B Caress  3 , D Clark Files  4
Affiliations
Review

Identification and Management of Acute Neuromuscular Respiratory Failure in the ICU

Jennifer T W Krall et al. Chest. 2023 Dec.

Abstract

Respiratory failure is a common and potentially life-threatening complication of neuromuscular diseases. Prompt recognition and accurate diagnosis of new or worsening chronic neuromuscular disease have important clinical management and prognostic implications. In this article, we present an approach to the acute presentation of undifferentiated neuromuscular respiratory failure in the ICU and guidance for determination and respiratory management of the underlying disorder.

Keywords: Guillain-Barré syndrome; ICU-acquired weakness; amyotrophic lateral sclerosis; myasthenia gravis; neuromuscular respiratory failure.

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Conflict of interest statement

Financial/Nonfinancial Disclosures The authors have reported to CHEST the following: J. B. C. has a grant from Catalyst Pharmaceuticals Inc and receives clinical trial support from MTB Pharma Inc and Amylyx Pharmaceuticals. The institution receives funding on behalf of D. C. F. from NIH, CDC, and Quantum Leap Healthcare Collaborative. D. C. F. has worked as a consultant for Cytovale and Medpace. None declared (J. T. W. K., A. C.).

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