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. 2024 Feb;46(2):386-397.
doi: 10.1002/hed.27592. Epub 2023 Dec 10.

Prognostic utility of preoperative platelet-to-albumin ratio in surgically treated oral cavity cancer patients

Yao-Te Tsai  1   2 , Ku-Hao Fang  2   3 , Ming-Hsien Tsai  2   4 , Chia-Hsuan Lai  2   5 , Chien-An Ko  1   2 , Ming-Shao Tsai  1   2 , Geng-He Chang  1   2 , Chun-Ta Liao  2   3 , Chung-Jan Kang  2   3 , Cheng-Ming Hsu  1   2 , Ethan I Huang  1   2 , Yi-Chan Lee  2   6 , Yuan-Hsiung Tsai  2   7 , Chih-Wei Luan  2   8
Affiliations

Prognostic utility of preoperative platelet-to-albumin ratio in surgically treated oral cavity cancer patients

Yao-Te Tsai et al. Head Neck. 2024 Feb.

Abstract

Background: This study aimed to explore the prognostic utility of the preoperative platelet-to-albumin ratio (PAR) among patients with oral cavity squamous cell carcinoma (OSCC).

Methods: We retrospectively reviewed of 355 patients with surgically-treated OSCC between 2008 and 2017. The optimal PAR cutoff for patient stratification was determined through X-tile analysis. Prognostic variables for disease-free survival (DFS) and overall survival (OS) were identified using Cox proportional hazards models. We developed a PAR-based nomogram to predict personalized OS.

Results: We determined the optimal PAR cutoff to be 7.45. A PAR of ≥7.45 was an independent negative prognostic factor for DFS and OS (hazard ratio = 1.748 and 2.386; p = 0.005 and p < 0.001, respectively). The developed nomogram demonstrates the practical utility of PAR and accurately predicts personalized OS.

Conclusions: The preoperative PAR is a promising and cost-effective prognostic biomarker for patients with surgically-treated OSCC; the PAR-based nanogram accurately predicts OS for such patients.

Keywords: disease-free survival; nomogram; oral cavity cancer; overall survival; platelet-to-albumin ratio.

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References

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