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. 2024 Apr;61(4):441-449.
doi: 10.1007/s00592-023-02211-y. Epub 2023 Dec 10.

No correlation between carotid intima-media thickness and long-term glycemic control in individuals with type 1 diabetes

Jussi Inkeri  1   2   3   4 , Valma Harjutsalo  2   4   5 , Juha Martola  1   6 , Jukka Putaala  7 , Per-Henrik Groop  8   9   10   11 , Daniel Gordin #  3   5 , Lena M Thorn #  2   4   12 ; FinnDiane Study Group
Collaborators, Affiliations

No correlation between carotid intima-media thickness and long-term glycemic control in individuals with type 1 diabetes

Jussi Inkeri et al. Acta Diabetol. 2024 Apr.

Abstract

Aims: To determine whether carotid intima-media thickness (CIMT), a surrogate marker of cardiovascular disease (CVD), is associated with long-term blood glucose control in individuals with type 1 diabetes (T1D).

Methods: We recruited 508 individuals (43.4% men; median age 46.1, IQR 37.8-55.9 years) with T1D (median diabetes duration of 30.4, IQR 21.2-40.8 years) in a cross-sectional retrospective sub-study, part of the Finnish Diabetic Nephropathy (FinnDiane) Study. Glycated hemoglobin (HbA1c) data were collected retrospectively over the course of ten years (HbA1c-meanoverall) prior to the clinical study visit that included a clinical examination, biochemical sampling, and ultrasound of the common carotid arteries.

Results: Individuals with T1D had a median CIMT of 606 μm (IQR 538-683 μm) and HbA1c of 8.0% (7.3-8.8%) during the study visit and HbA1c-meanoverall of 8.0% (IQR 7.3-8.8%). CIMT did not correlate with HbA1c (p = 0.228) at visit or HbA1c-meanoverall (p = 0.063). After controlling for relevant factors in multivariable linear regression analysis, only age was associated with CIMT (p < 0.001). After further dividing CIMT into quartiles, no correlation between long-term glucose control and CIMT (%, 1st 8.1 [IQR 7.2-8.9] vs 4th 7.9 [7.4-8.7], p = 0.730) was found.

Conclusions: We observed no correlation between long-term blood glucose control and CIMT in individuals with T1D. This finding suggests that the development of early signs of macrovascular atherosclerosis is not strongly affected by the glycemic control in people with T1D.

Keywords: Cardiovascular disease; Carotid intima-media thickness; Glycemic control; Type 1 diabetes.

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Conflict of interest statement

D.G. Lecture or Advisory Board Honoraria: Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Fresenius, GE Healthcare, Novo Nordisk, all outside the submitted work. J.M. Lecture Honoria Santen. P.-H.G. has received lecture honoraria from AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Elo Water, Genzyme, Medscape, Merck Sharp & Dohme (MSD), Mundipharma, Novartis, Novo Nordisk, PeerVoice, Sanofi, SCIARC, and is an advisory board member of AbbVie, Bayer, Boehringer Ingelheim, Eli Lilly, Janssen, Medscape, MSD, Mundipharma, Novartis, Novo Nordisk, and Sanofi. No other potential conflicts of interest relevant to this article were reported.

Figures

Fig. 1
Fig. 1
Carotid intima-media thickness (μm) by HbA1c (%) in individuals with type 1 diabetes (p = 0.228)
Fig. 2
Fig. 2
Carotid intima-media thickness (μm) by HbA1c-meanoverall (%) in individuals with type 1 diabetes (p = 0.063)
Fig. 3
Fig. 3
Carotid intima-media thickness (μm) by age in individuals with type 1 diabetes (p < 0.001)
See this image and copyright information in PMC

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