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Review
. 2024 Feb;54(2):e2350385.
doi: 10.1002/eji.202350385. Epub 2023 Dec 14.

Role of solute carrier transporters in regulating dendritic cell maturation and function

Lin Shao  1   2 , Mengxin Yang  3 , Tao Sun  4 , Haotang Xia  1 , Dan Du  5   6   7 , Xun Li  4 , Zuliang Jie  7
Affiliations
Free article
Review

Role of solute carrier transporters in regulating dendritic cell maturation and function

Lin Shao et al. Eur J Immunol. 2024 Feb.
Free article

Abstract

Dendritic cells (DCs) are specialized antigen-presenting cells that initiate and regulate innate and adaptive immune responses. Solute carrier (SLC) transporters mediate diverse physiological functions and maintain cellular metabolite homeostasis. Recent studies have highlighted the significance of SLCs in immune processes. Notably, upon activation, immune cells undergo rapid and robust metabolic reprogramming, largely dependent on SLCs to modulate diverse immunological responses. In this review, we explore the central roles of SLC proteins and their transported substrates in shaping DC functions. We provide a comprehensive overview of recent studies on amino acid transporters, metal ion transporters, and glucose transporters, emphasizing their essential contributions to DC homeostasis under varying pathological conditions. Finally, we propose potential strategies for targeting SLCs in DCs to bolster immunotherapy for a spectrum of human diseases.

Keywords: Dendritic cells; Immune regulation; Immunotherapy; Solute carrier transporters.

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