Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Nov 16;11(32):7806-7813.
doi: 10.12998/wjcc.v11.i32.7806.

Effect of anesthesia induction with butorphanol on postoperative nausea and vomiting: A randomized controlled trial

Fang Xie  1 , De-Feng Sun  2 , Lin Yang  3 , Zhong-Liang Sun  1
Affiliations

Effect of anesthesia induction with butorphanol on postoperative nausea and vomiting: A randomized controlled trial

Fang Xie et al. World J Clin Cases. .

Abstract

Background: Postoperative nausea and vomiting (PONV) are common complications that affect the recovery and well-being of elderly patients undergoing gastrointestinal laparoscopic surgery.

Aim: To investigate the effect of butorphanol on PONV in this patient population.

Methods: A total of 110 elderly patients (≥ 65 years old) who underwent gastrointestinal laparoscopic surgery were randomly assigned to receive butorphanol (40 μg/kg) or sufentanil (0.3 μg/kg) during anesthesia induction in a 1:1 ratio. The measured outcomes included the incidence of PONV at 48 h after surgery, intraoperative dose of propofol and remifentanil, Bruggrmann Comfort Scale score in the postanesthesia care unit (PACU), number of compressions for postoperative patient-controlled intravenous analgesia (PCIA), and time to first flatulence after surgery.

Results: The results revealed a noteworthy reduction in the occurrence of PONV at 24 h after surgery in the butorphanol group, when compared to the sufentanil group (T1: 23.64% vs 5.45%, T2: 43.64% vs 20.00%, P < 0.05). However, no significant variations were observed between the two groups, in terms of the clinical characteristics, such as the PONV or motion sickness history, intraoperative and postoperative 48-h total infusion volume and hemodynamic parameters, intraoperative dose of propofol and remifentanil, number of postoperative PCIA compressions, time until the first occurrence of postoperative flatulence, and incidence of PONV at 48 h post-surgery (all, P > 0.05). Furthermore, patients in the butorphanol group were more comfortable, when compared to patients in the sufentanil group in the PACU.

Conclusion: The present study revealed that butorphanol can be an efficacious substitute for sufentanil during anesthesia induction to diminish PONV within 24 h following gastrointestinal laparoscopic surgery in the elderly, simultaneously improving patient comfort in the PACU.

Keywords: Anesthesiology; Butorphanol; Enhanced recovery after surgery; Gastrointestinal surgery; Postoperative nausea and vomiting; Sufentanil.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Figures

Figure 1
Figure 1
The patient inclusion, randomization, and follow-up flowchart.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Gan TJ, Belani KG, Bergese S, Chung F, Diemunsch P, Habib AS, Jin Z, Kovac AL, Meyer TA, Urman RD, Apfel CC, Ayad S, Beagley L, Candiotti K, Englesakis M, Hedrick TL, Kranke P, Lee S, Lipman D, Minkowitz HS, Morton J, Philip BK. Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting. Anesth Analg. 2020;131:411–448. - PubMed
    1. Seyfried S, Herrle F, Schröter M, Hardt J, Betzler A, Rahbari NN, Reißfelder C. [Initial experiences with the implementation of the enhanced recovery after surgery (ERAS®) protocol] Chirurg. 2021;92:428–433. - PubMed
    1. Stoops S, Kovac A. New insights into the pathophysiology and risk factors for PONV. Best Pract Res Clin Anaesthesiol. 2020;34:667–679. - PubMed
    1. Sande TA, Laird BJA, Fallon MT. The Management of Opioid-Induced Nausea and Vomiting in Patients with Cancer: A Systematic Review. J Palliat Med. 2019;22:90–97. - PubMed
    1. Laffey DA, Kay NH. Premedication with butorphanol. A comparison with morphine. Br J Anaesth. 1984;56:363–367. - PubMed