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. 2023 Nov 22;60(4):298-303.
doi: 10.29399/npa.28162. eCollection 2023.

Investigation of Ongoing Denervation and Reinnervation in Amyotrophic Lateral Sclerosis by Using Concentric Needle Electrode with Single Fiber Electromyography Method

Pınar Bekdik  1 , Mehmet Barış Baslo  1
Affiliations

Investigation of Ongoing Denervation and Reinnervation in Amyotrophic Lateral Sclerosis by Using Concentric Needle Electrode with Single Fiber Electromyography Method

Pınar Bekdik et al. Noro Psikiyatr Ars. .

Abstract

Introduction: The aim of this study is to demonstrate the conduction disturbance at the neuromuscular junction in a cranial muscle by measuring jitter with a concentric needle (CN) electrode in the diagnosis of Amyotrophic Lateral Sclerosis (ALS) and to investigate the utility of evaluating the peak number as an ongoing reinnervation marker.

Method: Twelve patients diagnosed with ALS were included in this study. Single fiber electromyography (SFEMG) was performed using a CN electrode during the voluntary contraction of the right extensor digitorum communis (EDC) and left frontalis muscles.

Results: In SFEMG from the right EDC muscle, the mean jitter value was high in all of them. The average jitter calculated in EDC muscles was 57.76±24.17 μs. The mean jitter value in the frontal muscles was 28.91±10.21 μs. In all patients, the number of CN electrode peaks was more than 4 in the EDC muscle and above 4 in 91.67% of the frontal muscle.

Conclusion: Detection of high jitter in SFEMG examination indicates that the examined muscle undergoes a denervation-reinnervation process in the case of increased peak number values. When such a determination is made in the extremity muscles, it becomes important for the diagnosis of ALS.

Keywords: Amyotrophic lateral sclerosis; concentric needle electrode; neuromuscular jitter; peak number; single fiber electromyography.

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Conflict of interest statement

Conflict of Interest: The authors declared that there is no conflict of interest.

Figures

Figure 1
Figure 1
Frontal muscle single fiber EMG high jitter superimpose.
Figure 2
Figure 2
Frontal muscle single fiber EMG increased peak number.
Figure 3
Figure 3
Frontal muscle single fiber EMG high jitter superimpose.
See this image and copyright information in PMC

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