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. 2023 Dec 7;6(12):e1747.
doi: 10.1002/hsr2.1747. eCollection 2023 Dec.

Epigenetic age in African American adolescents with type 2 diabetes: A cross-sectional case-control study protocol

Christy Foster  1 , Olga Mamaeva  2 , Sadeep Shrestha  2 , Bertha Hidalgo  2
Affiliations

Epigenetic age in African American adolescents with type 2 diabetes: A cross-sectional case-control study protocol

Christy Foster et al. Health Sci Rep. .

Abstract

Background and aims: Type 2 diabetes (T2D) is a disease caused by a relative insulin deficiency compared to the significant insulin requirement needed by the body to achieve glycemic control. T2D in adolescence appears to be increasing in prevalence over the past several decades, necessitating studies to understand for the onset of the disease to occur early in the lifespan. Given the high burden of disease, specifically in young African American adolescents, our study chose to focus initially on feasibility of recruitment of this population.

Methods: Data was collected at a single study center at Children's of Alabama. The protocol was completed as part of routine care or at a study visit. The study team was able to leverage the Electronic Medical Record to prescreen eligible patients to discuss the study. A variety of times of day were utilized to improve likely of success with reaching potential participants. Inclusion criteria for patients with T2D was focused on the adolescent population (ages 12-18 years), with no history of an obesity syndrome. DNA methylation age will be calculated using the EPIC 850K array. Statistical analysis will be done using linear regression analysis, adjusting for covariates.

Conclusions: This study's aim was to screen and enroll young African American adolescents for a study investigating epigenetic aging and T2D. Our study found that more direct contact (face-to-face- or phone call) improve success of recruitment. Leveraging the electronic medical record also helped improve success with pre-screening participants. Challenges included recruiting participants who might come from long distances to a tertiary care center. Consolidating appointments helped improve the success of reaching these participants. Other challenges included frequent address changes and changed phone numbers. Close attention to the barriers as well as the successes will aid in understanding effective strategies for this important population.

Keywords: African Americans; adolescents; epigenetics; type 2 diabetes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Overview of study protocol.
See this image and copyright information in PMC

References

    1. American Diabetes Association . Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010;33(suppl 1):S62‐S69. - PMC - PubMed
    1. American Diabetes Association . Type 2 diabetes in children and adolescents. Diabetes Care. 2000;23(3):381‐389. - PubMed
    1. Pal S, Tyler JK. Epigenetics and aging. Sci Adv. 2016;2(7):e1600584. - PMC - PubMed
    1. Agarwal P, Wicklow BA, Dart AB, et al. Integrative analysis reveals novel associations between DNA methylation and the serum metabolome of adolescents with type 2 diabetes: A cross‐sectional study. Front Endocrinol. 2022;13:934706. - PMC - PubMed
    1. Gumbs AA, Gogol M, Spolverato G, Taher H, Chouillard EK. Systematic review of the integrative medicine recommendations for patients with pancreatic cancer. Surgeries. 2021;2(2):216‐230.

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