Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2024 Apr;45(4):1399-1408.
doi: 10.1007/s10072-023-07254-1. Epub 2023 Dec 11.

Impulse control disorders in Parkinson's disease patients treated with pramipexole and ropinirole: a systematic review and meta-analysis

Lenise G Soileau  1 , Norris C Talbot  1 , Nicholas R Storey  1 , Noah J Spillers  1 , James V D'antoni  1 , Peter C Carr  2 , Connor M Galardo  3 , Patil Shilpadevi  4 , Shahab Ahmadzadeh  4 , Sahar Shekoohi  5 , Alan D Kaye  4   6
Affiliations
Meta-Analysis

Impulse control disorders in Parkinson's disease patients treated with pramipexole and ropinirole: a systematic review and meta-analysis

Lenise G Soileau et al. Neurol Sci. 2024 Apr.

Abstract

Background: This analysis is the first systematic review and meta-analysis assessing occurrences of ICD in PD patients treated with oral DAs: ropinirole (ROP) and pramipexole (PRX). This study compares the two oral DAs to a transdermal patch, rotigotine (RTG).

Methods: We performed an extensive systematic search for eligible studies from PubMed, Embase, Cochrane Library, and Google Scholar. The data was analyzed by various software, including EndNote, Rayyan, PRISM, and RevMan. Two studies incorporating 658 patients collectively were assessed.

Results: This meta-analysis shows a significant correlation between the usage of PRX (25.3%) or ROP (21.8%) and the development of ICD in PD patients. Compared to the transdermal patch, RTG, PRX was found to have a significant relative risk (P < 0.0001) of 3.46 (95% CI 2.07-5.76), and ROP was found to have a significant relative risk (P < 0.0001) of 2.98 (95% CI 1.77-5.02). The data collected shows RTG is approximately three times less likely to cause ICDs than oral PRX and ROP.

Conclusion: The present investigation provides insight into ICD occurrences with PRX, ROP, and RTG to allow physicians to make more informed decisions on risk versus reward when deciding how to treat a PD patient with these drugs. However, related to various disclosed limitations, our conclusion cannot provide definitive practice protocols.

Keywords: Impulse control disorders; Parkinson’s disease; Pramipexole; Ropinirole; Rotigotine.

PubMed Disclaimer

References

    1. McHugh PC, Buckley DA (2015) The structure and function of the dopamine transporter and its role in CNS diseases. Vitam Horm 98:339–369 - DOI - PubMed
    1. Klein MO, Battagello DS, Cardoso AR, Hauser DN, Bittencourt JC, Correa RG (2019) Dopamine: functions, signaling, and association with neurological diseases. Cell Mol Neurobiol 39(1):31–59 - DOI - PubMed
    1. Paus T (2001) Primate anterior cingulate cortex: where motor control, drive and cognition interface. Nat Rev Neurosci 2(6):417–424 - DOI - PubMed
    1. Luciana M, Collins PF, Depue RA (1998) Opposing roles for dopamine and serotonin in the modulation of human spatial working memory functions. Cereb Cortex 8(3):218–226 - DOI - PubMed
    1. Depue RA, Collins PF (1999) Neurobiology of the structure of personality: dopamine, facilitation of incentive motivation, and extraversion. Behav Brain Sci 22(3):491–517; discussion 518–569

MeSH terms

LinkOut - more resources