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1 Institute for Global Health, University College London, London, United Kingdom.
2 Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus.
3 Division of Infectious Diseases, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio.
4 Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio.
5 Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee.
1 Institute for Global Health, University College London, London, United Kingdom.
2 Center for Vaccines and Immunity, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus.
3 Division of Infectious Diseases, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio.
4 Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio.
5 Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee.
This cohort study evaluates respiratory syncytial virus (RSV)–related hospitalizations and disease severity from 2012 to 2023 in children younger than 5 years.
Conflict of Interest Disclosures: Dr Ramilo reported receiving a grant from the National Institutes of Health (NIH) during the conduct of the study; personal fees from Pfizer, Sanofi, Astra Zeneca, and Merck outside the submitted work; and grants to institution from Merck, Janssen, Bill & Melinda Gates Foundation, National Institute of Allergy and Infectious Diseases, and Eunice Kennedy Shriver National Institute of Child Health and Human Development outside the submitted work. Dr Mejias reported receiving a grant from the NIH during the conduct of the study; grants to institution from Janssen and Merck outside the submitted work; personal fees from Sanofi-Pasteur, Astra Zeneca, and Pfizer outside the submitted work. No other disclosures were reported.
Figures
Figure.. Hospitalization Trends by Age in Children…
Figure.. Hospitalization Trends by Age in Children Younger Than 5 Years With Respiratory Syncytial Virus…
Figure.. Hospitalization Trends by Age in Children Younger Than 5 Years With Respiratory Syncytial Virus (RSV) Infection Before and After the COVID-19 Pandemic
The proportion of hospitalized infants younger than 6 months (P for trend <.001) and 6 months to younger than 12 months (P for trend = .08) decreased over time. Hospitalizations in children aged 1 year to younger than 2 years (P for trend = .004) and 2 years to younger than 5 years (P for trend <.001) significantly increased during the pandemic.
Hamid S, Winn A, Parikh R, et al. . Seasonality of respiratory syncytial virus: United States, 2017-2023. MMWR Morb Mortal Wkly Rep. 2023;72(14):355-361. doi:10.15585/mmwr.mm7214a1
-
DOI
-
PMC
-
PubMed
Halabi KC, Wang H, Leber AL, Sánchez PJ, Ramilo O, Mejias A. Respiratory syncytial virus and SARS-CoV-2 coinfections in children. Pediatr Pulmonol. 2022;57(12):3158-3160. doi:10.1002/ppul.26127
-
DOI
-
PMC
-
PubMed
Rao S, Armistead I, Messacar K, et al. . Shifting epidemiology and severity of respiratory syncytial virus in children during the COVID-19 pandemic. JAMA Pediatr. 2023;177(7):730-732. doi:10.1001/jamapediatrics.2023.1088
-
DOI
-
PMC
-
PubMed
Nygaard U, Hartling UB, Nielsen J, et al. . Hospital admissions and need for mechanical ventilation in children with respiratory syncytial virus before and during the COVID-19 pandemic: a Danish nationwide cohort study. Lancet Child Adolesc Health. 2023;7(3):171-179. doi:10.1016/S2352-4642(22)00371-6
-
DOI
-
PMC
-
PubMed
Adams G, Moreno GK, Petros BA, et al. . Viral lineages in the 2022 RSV surge in the United States. N Engl J Med. 2023;388(14):1335-1337. doi:10.1056/NEJMc2216153
-
DOI
-
PMC
-
PubMed