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. 1986 Nov;334(3):253-60.
doi: 10.1007/BF00508779.

Effect of repeated amiflamine administration on serotonergic and noradrenergic neurotransmission: electrophysiological studies in the rat CNS

P Blier, C de Montigny, A J Azzaro

Effect of repeated amiflamine administration on serotonergic and noradrenergic neurotransmission: electrophysiological studies in the rat CNS

P Blier et al. Naunyn Schmiedebergs Arch Pharmacol. 1986 Nov.

Abstract

Amiflamine is a selective and reversible inhibitor of monoamine oxidase (MAO) type A which exerts a preferential effect on serotonin (5-HT) catabolism. The present studies were undertaken to compare the effects of repeated administration of amiflamine (2 mg/kg, twice daily) on several aspects of the functioning of the 5-HT and norepinephrine (NE) systems in the rat CNS. The activity of MAO-A and B was assessed in forebrain slices and the whole brain contents of the neurotransmitters and their metabolites were determined by HPLC after 2-, 7- and 21-day treatments. MAO-A was inhibited by about 50% 2 h after the last dose and its activity was back to normal in rats sacrificed 12 h after the last dose. The activity of MAO-B was unaffected two or 12 h after the last dose. Whole brain concentration of 5-HT was increased to a greater degree than that of NE following repeated administration of amiflamine. These increases in 5-HT and NE were accompanied by decreased levels of their respective metabolites 5-hydroxy-indoleacetic acid and 3-methoxy-4-hydroxyphenylethyleneglycol. The firing activity of dorsal raphe 5-HT neurons, but not that of NE neurons, was markedly decreased 2-6 h after the last dose of a 2-day treatment. However, 2-6 h after a 21-day treatment, the firing activity of 5-HT neurons was back to normal, whereas that of NE neurons was decreased by 30%.(ABSTRACT TRUNCATED AT 250 WORDS)

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References

    1. J Chromatogr. 1981 Jan 2;222(1):107-11 - PubMed
    1. J Neural Transm. 1984;60(3-4):265-71 - PubMed
    1. Neuroscience. 1985 Dec;16(4):949-55 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1986 Aug;333(4):342-8 - PubMed
    1. J Neural Transm. 1981;51(3-4):233-44 - PubMed

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