Retraction Note: Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Jeffrey Patterson-Fortin^{1

2}, Heta Jadhav¹, Constantia Pantelidou^{1

3}, Tin Phan⁴, Carter Grochala^{4

5}, Anita K Mehta^{6

7}, Jennifer L Guerriero⁶, Gerburg M Wulf⁸, Brian M Wolpin^{1

2

9}, Ben Z Stanger¹⁰, Andrew J Aguirre^{1

2

9}, James M Cleary^{1

2

9}, Alan D D'Andrea^{4

11}, Geoffrey I Shapiro^{12

13

14}

Affiliations

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
² Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
³ Bayer Pharmaceuticals, Cambridge, MA, USA.
⁴ Department of Radiation Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
⁵ Arpeggio, Boulder, CO, USA.
⁶ Department of Surgical Oncology and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
⁷ Sanofi, Cambridge, MA, USA.
⁸ Department of Medicine, Division of Hematology-Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
⁹ Hale Family Center for Pancreatic Cancer Research, Dana-Farber Cancer Institute, Boston, MA, USA.
¹⁰ Department of Medicine, Division of Gastroenterology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
¹¹ Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, MA, USA.
¹² Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. geoffrey_shapiro@dfci.harvard.edu.
¹³ Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. geoffrey_shapiro@dfci.harvard.edu.
¹⁴ Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, MA, USA. geoffrey_shapiro@dfci.harvard.edu.

Jeffrey Patterson-Fortin et al. Nat Commun. 2023.

. 2023 Dec 11;14(1):8193.

doi: 10.1038/s41467-023-43803-0.

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
² Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
³ Bayer Pharmaceuticals, Cambridge, MA, USA.
⁴ Department of Radiation Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.
⁵ Arpeggio, Boulder, CO, USA.
⁶ Department of Surgical Oncology and Harvard Medical School, Brigham and Women's Hospital, Boston, MA, USA.
⁷ Sanofi, Cambridge, MA, USA.
⁸ Department of Medicine, Division of Hematology-Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
⁹ Hale Family Center for Pancreatic Cancer Research, Dana-Farber Cancer Institute, Boston, MA, USA.
¹⁰ Department of Medicine, Division of Gastroenterology, Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
¹¹ Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, MA, USA.
¹² Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. geoffrey_shapiro@dfci.harvard.edu.
¹³ Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. geoffrey_shapiro@dfci.harvard.edu.
¹⁴ Center for DNA Damage and Repair, Dana-Farber Cancer Institute, Boston, MA, USA. geoffrey_shapiro@dfci.harvard.edu.

No abstract available

Retraction of

Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer.
Patterson-Fortin J, Jadhav H, Pantelidou C, Phan T, Grochala C, Mehta AK, Guerriero JL, Wulf GM, Wolpin BM, Stanger BZ, Aguirre AJ, Cleary JM, D'Andrea AD, Shapiro GI. Patterson-Fortin J, et al. Nat Commun. 2023 Mar 13;14(1):1390. doi: 10.1038/s41467-023-37096-6. Nat Commun. 2023. Retraction in: Nat Commun. 2023 Dec 11;14(1):8193. doi: 10.1038/s41467-023-43803-0. PMID: 36914658 Free PMC article. Retracted.