Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec 11;23(1):434.
doi: 10.1186/s12876-023-03073-y.

Dietary and lifestyle indices for hyperinsulinemia and colorectal cancer risk: a case-control study

Affiliations

Dietary and lifestyle indices for hyperinsulinemia and colorectal cancer risk: a case-control study

Pegah Hadi Sicahni et al. BMC Gastroenterol. .

Abstract

Background: The incidence of colorectal cancer (CRC) has increased in Iran, and determining the dietary patterns that can contribute to reducing or increasing the risk of CRC will help better control this disease. Therefore, in the current study, we assessed the association between the empirical lifestyle index for hyperinsulinemia (ELIH) and the empirical dietary index for hyperinsulinemia (EDIH) with the CRC odds.

Methods: The present case (n = 71)-control (n = 142) study was carried out in several CRC surgical units of hospitals in Tehran, Iran. A semi-quantitative food frequency questionnaire containing 168 items was used to assess participants' dietary intakes. The EDIH and ELIH scores were calculated by food groups and some variables such as body mass index and physical activity. Logistic regression models were applied to evaluate the association between the EDIH and ELIH scores with CRC odds.

Results: According to baseline features of the study participants, there were significant differences between the controls and cases in ELIH score, fiber intake, taking aspirin, and family history of CRC in first- and second-degree relatives. Also, we found that the odds of CRC increased significantly in the last tertile compared to the first tertile in EDIH and ELIH in the adjusted model (odds ratio (OR) = 3.12; 95% confidence interval (CI): 1.30-7.48 and OR = 4.72; 95% CI: 1.15-19.39, respectively).

Conclusions: In conclusion, the result of this study indicated that CRC odds was significantly greater in subjects with higher EDIH and ELIH scores. Also, according to the results of this study, lifestyle and diet with insulinemic potential can influence the CRC risk.

Keywords: Colorectal cancer; Colorectal neoplasms; Diet; Hyperinsulinemia; Iranian; Lifestyle; Pattern.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of the study

References

    1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. Cancer J Clin. 2019;69(1):7–34. doi: 10.3322/caac.21551. - DOI - PubMed
    1. Xi Y, Xu P. Global Colorectal cancer burden in 2020 and projections to 2040. Translational Oncol. 2021;14(10):101174. doi: 10.1016/j.tranon.2021.101174. - DOI - PMC - PubMed
    1. O’Sullivan DE, Sutherland RL, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR. Risk factors for early-onset Colorectal Cancer: a systematic review and Meta-analysis. Clin Gastroenterol Hepatol. 2022;20(6):1229–1240e1225. doi: 10.1016/j.cgh.2021.01.037. - DOI - PubMed
    1. Bruce W, Corpet D. The colonic protein fermentation and insulin resistance hypotheses for colon Cancer etiology: experimental tests using precursor lesions. Eur J Cancer Prev. 1996;5(6):41–7. doi: 10.1097/00008469-199612002-00007. - DOI - PubMed
    1. Wong M, Holdaway I. Insulin binding by normal and neoplastic colon tissue. Int J Cancer. 1985;35(3):335–41. doi: 10.1002/ijc.2910350309. - DOI - PubMed