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. 2023 Jul:2023:1-4.
doi: 10.1109/EMBC40787.2023.10341101.

Hyperlocal Spatial Flows in BOLD fMRI Expose Novel Brain-Based Correlates of Schizophrenia

Robyn L Miller, Victor M Vergara, Vince D Calhoun

Hyperlocal Spatial Flows in BOLD fMRI Expose Novel Brain-Based Correlates of Schizophrenia

Robyn L Miller et al. Annu Int Conf IEEE Eng Med Biol Soc. 2023 Jul.

Abstract

While analysis of temporal signal fluctuations has long been a fixture of blood oxygenation-level dependent (BOLD) functional magnetic resonance imaging (fMRI) research, the role of spatially localized directional diffusion in both signal propagation and emergent large-scale functional integration remains almost entirely neglected. We are proposing an extensible framework to capture and analyze spatially localized fMRI directional signal flow dynamics. The approach is validated in a large resting-state fMRI schizophrenia study where it uncovers significant and novel relationships between hyperlocal spatial dynamics and subject diagnostic status.

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