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Review
. 2024 Feb;38(2):797-838.
doi: 10.1002/ptr.8083. Epub 2023 Dec 11.

Natural compounds as obesity pharmacotherapies

Xin-Yuan Zhao  1 , Ji-Qiu Wang  2 , G Gregory Neely  3 , Yan-Chuan Shi  4   5 , Qiao-Ping Wang  1   6   7
Affiliations
Review

Natural compounds as obesity pharmacotherapies

Xin-Yuan Zhao et al. Phytother Res. 2024 Feb.

Abstract

Obesity has become a serious global public health problem, affecting over 988 million people worldwide. Nevertheless, current pharmacotherapies have proven inadequate. Natural compounds have garnered significant attention due to their potential antiobesity effects. Over the past three decades, ca. 50 natural compounds have been evaluated for the preventive and/or therapeutic effects on obesity in animals and humans. However, variations in the antiobesity efficacies among these natural compounds have been substantial, owing to differences in experimental designs, including variations in animal models, dosages, treatment durations, and administration methods. The feasibility of employing these natural compounds as pharmacotherapies for obesity remained uncertain. In this review, we systematically summarized the antiobesity efficacy and mechanisms of action of each natural compound in animal models. This comprehensive review furnishes valuable insights for the development of antiobesity medications based on natural compounds.

Keywords: energy expenditure; food intake; natural compounds; obesity; pharmacotherapies; weight loss efficacy.

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References

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