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Comment
. 2023 Dec 12;13(12):2507-2509.
doi: 10.1158/2159-8290.CD-23-1059.

Re-"Formate" T-cell Antitumor Responses

Mei-Chun Lin  1   2   3 , Sofie Hedlund Moller  1   3 , Ping-Chih Ho  1   3
Affiliations
Comment

Re-"Formate" T-cell Antitumor Responses

Mei-Chun Lin et al. Cancer Discov. .

Abstract

Rowe and colleagues discover that one-carbon (1C) metabolism rewiring occurs upon T-cell activation to support proliferation and cytolytic activity in CD8+ T cells and that supplementation of 1C donor formate rescues the dysfunctional T cells and their responsiveness to anti-PD-1 in selective tumor-infiltrated T-cell subsets. This finding represents an attractive strategy to overcome a metabolic vulnerability in the tumor microenvironment and improve the efficacy of immune checkpoint blockade. See related article by Rowe et al., p. 2566 (8).

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