Midnolin-proteasome pathway for protein degradation

Abstract

Overexpression of immediate-early genes (IEGs) has been linked to was associated with cancer progression and prognosis. In a recent study, Gu et al. reported the midnolin-proteasome pathway, a novel ubiquitin-independent proteasomal degradation. 1 The study provided the mechanism of rapid degradation for nuclear proteins with high unsteadiness. Targeting the midnolin-proteasome pathway might be beneficial for cancer therapy.

FIGURE 1

Protein degradation pathways. Degradation of specific proteins can be divided into two categories: proteasome pathway and lysosome‐autophagy pathway. The former could be further classified into the ubiquitin‐proteasome pathway and midnolin‐proteasome pathway, which was a novel ubiquitination‐independent protein degradation pathway discovered by Gu et al. The latter could be through microautophagy, macroautophagy, and chaperone‐mediated autophagy.