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Comment
. 2024 Feb 16;30(4):652-654.
doi: 10.1158/1078-0432.CCR-23-3087.

In Search of Lost Biomarker for Immunotherapy in Small Cell Lung Cancer

Christian Rolfo  1 , Alessandro Russo  2
Affiliations
Comment

In Search of Lost Biomarker for Immunotherapy in Small Cell Lung Cancer

Christian Rolfo et al. Clin Cancer Res. .

Abstract

Chemo-immunotherapy is the current standard of care for extensive-stage small cell lung cancer, but predictive biomarkers are lacking. In a recent article, the authors report the predictive role of programmed death ligand-1 expression and tissue tumor mutational burden on durvalumab ± tremelimumab + platinum-etoposide efficacy. See related article by Paz-Ares et al., p. 824.

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