Hepatocellular carcinoma in survivors after Fontan operation: a case-control study

Yuli Y Kim^{1

2}, Gentian Lluri³, Christiane Haeffele⁴, Tami Daugherty⁴, Richard A Krasuski⁵, John D Serfas⁵, R Andrew de Freitas⁶, Avaliese Porlier⁶, Adam M Lubert⁷, Fred M Wu^{8

9}, Anne Marie Valente^{8

9}, Eric V Krieger^{10

11}, Jonathan Buber¹⁰, Fred H Rodriguez 3rd¹², Scott Gaignard¹², Anita Saraf¹³, Morgan Hindes¹³, Michael G Earing¹⁴, Matthew J Lewis¹⁵, Marlon S Rosenbaum¹⁵, Ali N Zaidi¹⁶, Kali Hopkins¹⁶, Elisa A Bradley¹⁷, Ari M Cedars¹⁸, Jong L Ko¹⁸, Wayne J Franklin^{19

20}, Abby Frederickson¹⁹, Salil Ginde²¹, Jasmine Grewal²², Annique Nyman², Jungwon Min²³, Charlotte Schluger²³, Elizabeth Rand²⁴, Benjamin E Rosenthal²⁵, Moira Hilscher²⁶, Jack Rychik², Maarouf A Hoteit²⁶

Affiliations

¹ Division of Cardiology, Hospital of the University of Pennsylvania, Perelman Center for Advanced Medicine, 2nd Floor E. Pavilion, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
² Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
³ Ahmanson/UCLA Adult Congenital Heart Disease Center, Division of Cardiology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
⁴ Division of Cardiovascular Medicine, Stanford Medicine, Stanford, CA, USA.
⁵ Duke University Health System, Durham, NC, USA.
⁶ Division of Pediatric Cardiology, Anne & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
⁷ Cincinnati Children's Hospital Heart Institute, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.
⁸ Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
⁹ Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.
¹⁰ University of Washington Medical Center, University of Washington School of Medicine, Seattle, WA, USA.
¹¹ Seattle Children's Hospital, Seattle, WA, USA.
¹² Department of Pediatrics, Emory University, Atlanta, GA, USA.
¹³ Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
¹⁴ The University of Chicago Medicine, Chicago, IL, USA.
¹⁵ Division of Cardiology, Columbia University Irving Medical Center, NewYork, NY, USA.
¹⁶ Mount Sinai Adult Congenital Heart Disease Center, Mount Sinai Heart, NewYork, NY, USA.
¹⁷ Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.
¹⁸ Department of Pediatrics, Johns Hopkins Department of Medicine, Baltimore, MD, USA.
¹⁹ Division of Pediatric Cardiology, Phoenix Children's Hospital, Phoenix, AZ, USA.
²⁰ Department of Child Health, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.
²¹ Department of Pediatrics, Children's Hospital of Wisconsin, Milwaukee, WI, USA.
²² Division of Cardiology, St.Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
²³ Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
²⁴ Division of Hepatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
²⁵ Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
²⁶ Division of Hepatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

PMID: 38085593
PMCID: PMC11491280
DOI: 10.1093/eurheartj/ehad788

Hepatocellular carcinoma in survivors after Fontan operation: a case-control study

Yuli Y Kim et al. Eur Heart J. 2024.

. 2024 Apr 21;45(16):1477-1480.

doi: 10.1093/eurheartj/ehad788.

Authors

Affiliations

¹ Division of Cardiology, Hospital of the University of Pennsylvania, Perelman Center for Advanced Medicine, 2nd Floor E. Pavilion, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
² Division of Cardiology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
³ Ahmanson/UCLA Adult Congenital Heart Disease Center, Division of Cardiology, Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
⁴ Division of Cardiovascular Medicine, Stanford Medicine, Stanford, CA, USA.
⁵ Duke University Health System, Durham, NC, USA.
⁶ Division of Pediatric Cardiology, Anne & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, USA.
⁷ Cincinnati Children's Hospital Heart Institute, Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.
⁸ Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
⁹ Department of Cardiology, Boston Children's Hospital, Boston, MA, USA.
¹⁰ University of Washington Medical Center, University of Washington School of Medicine, Seattle, WA, USA.
¹¹ Seattle Children's Hospital, Seattle, WA, USA.
¹² Department of Pediatrics, Emory University, Atlanta, GA, USA.
¹³ Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
¹⁴ The University of Chicago Medicine, Chicago, IL, USA.
¹⁵ Division of Cardiology, Columbia University Irving Medical Center, NewYork, NY, USA.
¹⁶ Mount Sinai Adult Congenital Heart Disease Center, Mount Sinai Heart, NewYork, NY, USA.
¹⁷ Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA.
¹⁸ Department of Pediatrics, Johns Hopkins Department of Medicine, Baltimore, MD, USA.
¹⁹ Division of Pediatric Cardiology, Phoenix Children's Hospital, Phoenix, AZ, USA.
²⁰ Department of Child Health, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.
²¹ Department of Pediatrics, Children's Hospital of Wisconsin, Milwaukee, WI, USA.
²² Division of Cardiology, St.Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
²³ Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
²⁴ Division of Hepatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
²⁵ Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
²⁶ Division of Hepatology, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.

PMID: 38085593
PMCID: PMC11491280
DOI: 10.1093/eurheartj/ehad788

No abstract available

Keywords: Congenital heart disease; Fontan operation; Fontan-associated liver disease; Hepatocellular carcinoma.

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References

1. Rychik J, Veldtman G, Rand E, Russo P, Rome JJ, Krok K, et al. The precarious state of the liver after a Fontan operation: summary of a multidisciplinary symposium. Pediatr Cardiol 2012;33:1001–12. 10.1007/s00246-012-0315-7 - DOI - PMC - PubMed
1. Egbe AC, Poterucha JT, Warnes CA, Connolly HM, Baskar S, Ginde S, et al. Hepatocellular carcinoma after Fontan operation: multicenter case series. Circulation 2018;138:746–8. 10.1161/CIRCULATIONAHA.117.032717 - DOI - PubMed
1. Ohuchi H, Hayama Y, Nakajima K, Kurosaki K, Shiraishi I, Nakai M. Incidence, predictors, and mortality in patients with liver cancer after Fontan operation. J Am Heart Assoc 2021;10:e016617. 10.1161/JAHA.120.016617 - DOI - PMC - PubMed
1. Inuzuka R, Nii M, Inai K, Shimada E, Shinohara T, Kogiso T, et al. Predictors of liver cirrhosis and hepatocellular carcinoma among perioperative survivors of the Fontan operation. Heart 2023;109:276–82. 10.1136/heartjnl-2022-320940 - DOI - PubMed
1. American College of Radiology . Liver Imaging Reporting and Data System (LI-RADS) v2018. ACR. 2018. https://www.acr.org/-/media/ACR/Files/RADS/LI-RADS/LI-RADS-2018-Core.pdf... (14 April 2023, date last accessed).

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Hepatocellular carcinoma in survivors after Fontan operation: a case-control study

Affiliations

Hepatocellular carcinoma in survivors after Fontan operation: a case-control study

Authors

Affiliations

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical