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. 2024 Mar 1;143(3):336-345.
doi: 10.1097/AOG.0000000000005480. Epub 2023 Dec 12.

Performance Characteristics of Sepsis Screening Tools During Antepartum and Postpartum Admissions

Melissa E Bauer  1 , Matt Fuller, Vesela Kovacheva, Rania Elkhateb, Kristen Azar, Morgan Caldwell, Vanna Chiem, Mindy Foster, Ronald Gibbs, Brenna L Hughes, Rebecca Johnson, Nobin Kottukapally, Melissa G Rosenstein, Magdalena Sanz Cortes, Laurence E Shields, Sylvia Sudat, Caitlin D Sutton, Paloma Toledo, Austin Traylor, Kurt Wharton, Elliott Main
Affiliations

Performance Characteristics of Sepsis Screening Tools During Antepartum and Postpartum Admissions

Melissa E Bauer et al. Obstet Gynecol. .

Abstract

Objective: To evaluate the performance characteristics of existing screening tools for the prediction of sepsis during antepartum and postpartum readmissions.

Methods: This was a case-control study using electronic health record data obtained between 2016 and 2021 from 67 hospitals for antepartum sepsis admissions and 71 hospitals for postpartum readmissions up to 42 days. Patients in the sepsis case group were matched in a 1:4 ratio to a comparison cohort of patients without sepsis admitted antepartum or postpartum. The following screening criteria were evaluated: the CMQCC (California Maternal Quality Care Collaborative) initial sepsis screen, the non-pregnancy-adjusted SIRS (Systemic Inflammatory Response Syndrome), the MEWC (Maternal Early Warning Criteria), UKOSS (United Kingdom Obstetric Surveillance System) obstetric SIRS, and the MEWT (Maternal Early Warning Trigger Tool). Time periods were divided into early pregnancy (less than 20 weeks of gestation), more than 20 weeks of gestation, early postpartum (less than 3 days postpartum), and late postpartum through 42 days. False-positive screening rates, C-statistics, sensitivity, and specificity were reported for each overall screening tool and each individual criterion.

Results: We identified 525 patients with sepsis during an antepartum hospitalization and 728 patients with sepsis during a postpartum readmission. For early pregnancy and more than 3 days postpartum, non-pregnancy-adjusted SIRS had the highest C-statistics (0.78 and 0.83, respectively). For more than 20 weeks of gestation and less than 3 days postpartum, the pregnancy-adjusted sepsis screening tools (CMQCC and UKOSS) had the highest C-statistics (0.87-0.94). The MEWC maintained the highest sensitivity rates during all time periods (81.9-94.4%) but also had the highest false-positive rates (30.4-63.9%). The pregnancy-adjusted sepsis screening tools (CMQCC, UKOSS) had the lowest false-positive rates in all time periods (3.9-10.1%). All tools had the lowest C-statistics in the periods of less than 20 weeks of gestation and more than 3 days postpartum.

Conclusion: For admissions early in pregnancy and more than 3 days postpartum, non-pregnancy-adjusted sepsis screening tools performed better than pregnancy-adjusted tools. From 20 weeks of gestation through up to 3 days postpartum, using a pregnancy-adjusted sepsis screening tool increased sensitivity and minimized false-positive rates. The overall false-positive rate remained high.

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Conflict of interest statement

Financial Disclosure Melissa Bauer disclosed receiving consulting fees from the Institute for Healthcare Innovation, and travel compensation from National AIM to present the ACOG/AIM Sepsis Bundle at the ACOG Annual Conference. Vesela Kovacheva disclosed receiving consulting fees from Avania CRO unrelated to the current study. Paloma Toledo disclosed receiving speaker fees from Pacira Biosciences, Inc. Kurt Wharton disclosed receiving consulting fees from Molnlycke. The other authors did not report any potential conflicts of interest.

Figures

Figure 1.
Figure 1.
Study flowchart for antepartum and postpartum admissions. ICD-10, International Classification of Diseases 10th Revision.
See this image and copyright information in PMC

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