Implementing precision methods in personalizing psychological therapies: Barriers and possible ways forward

Anne-Katharina Deisenhofer¹, Michael Barkham², Esther T Beierl³, Brian Schwartz⁴, Katie Aafjes-van Doorn⁵, Christopher G Beevers⁶, Isabel M Berwian⁷, Simon E Blackwell⁸, Claudi L Bockting⁹, Eva-Lotta Brakemeier¹⁰, Gary Brown¹¹, Joshua E J Buckman¹², Louis G Castonguay¹³, Claire E Cusack¹⁴, Tim Dalgleish¹⁵, Kim de Jong¹⁶, Jaime Delgadillo², Robert J DeRubeis¹⁷, Ellen Driessen¹⁸, Jill Ehrenreich-May¹⁹, Aaron J Fisher²⁰, Eiko I Fried²¹, Jessica Fritz²², Toshi A Furukawa²³, Claire M Gillan²⁴, J M Gómez Penedo²⁵, Peter F Hitchcock²⁶, Stefan G Hofmann²⁷, Steven D Hollon²⁸, Nicholas C Jacobson²⁹, Daniel R Karlin³⁰, Chi Tak Lee³¹, Cheri A Levinson¹⁴, Lorenzo Lorenzo-Luaces³², Riley McDanal³³, Danilo Moggia⁴, Mei Yi Ng³⁴, Lesley A Norris³⁵, Vikram Patel³⁶, Marilyn L Piccirillo³⁷, Stephen Pilling¹², Julian A Rubel³⁸, Gonzalo Salazar-de-Pablo³⁹, Jessica L Schleider⁴⁰, Paula P Schnurr⁴¹, Stephen M Schueller⁴², Greg J Siegle⁴³, Rudolf Uher⁴⁴, Ed Watkins⁴⁵, Christian A Webb⁴⁶, Shannon Wiltsey Stirman⁴⁷, Laure Wynants⁴⁸, Soo Jeong Youn⁴⁹, Sigal Zilcha-Mano⁵⁰, Wolfgang Lutz⁴, Zachary D Cohen⁵¹

Affiliations

¹ University of Trier, Germany. Electronic address: deisenhofer@uni-trier.de.
² University of Sheffield, UK.
³ University of Oxford, UK.
⁴ University of Trier, Germany.
⁵ Yeshiva University, USA.
⁶ The University of Texas at Austin, USA.
⁷ Princeton University, USA.
⁸ Ruhr University Bochum, Germany.
⁹ AmsterdamUMC, Department of Psychiatry, Research Program Amsterdam Public Health and Centre for Urban Mental Health, University of Amsterdam, the Netherlands.
¹⁰ University of Greifswald, Germany.
¹¹ Royal Holloway University of London, UK.
¹² University College London, UK.
¹³ Pennsylvania State University, USA.
¹⁴ University of Louisville, USA.
¹⁵ University of Cambridge, UK.
¹⁶ Leiden University, Institute of Psychology, USA.
¹⁷ University of Pennsylvania, USA.
¹⁸ Radboud University, USA.
¹⁹ University of Miami, USA.
²⁰ University of California, Berkeley, USA.
²¹ Leiden University, USA.
²² University of Cambridge, UK; Philipps University of Marburg, Germany.
²³ Kyoto University, USA.
²⁴ School of Psychology, Trinity College Institute for Neuroscience, And Global Brain Health Institute, Trinity College Dublin, USA.
²⁵ University of Buenos Aires, USA.
²⁶ Emory University, USA.
²⁷ Philipps University of Marburg, Germany.
²⁸ Vanderbilt University, USA.
²⁹ Dartmouth Geisel School of Medicine, USA.
³⁰ MindMed, Inc., Tufts University School of Medicine, USA.
³¹ Trinity College Dublin, USA.
³² Indiana University-Bloomington, USA.
³³ Stony Brook University, USA.
³⁴ Florida International University, USA.
³⁵ Warren Alpert Medical School of Brown University, USA.
³⁶ Harvard Medical School, USA.
³⁷ University of Washington, USA.
³⁸ Osnabrück University, USA.
³⁹ King's College London and South London and Maudsley NHS Foundation Trust, USA.
⁴⁰ Stony Brook University and Feinberg School of Medicine Northwestern University, USA.
⁴¹ National Center for PTSD and Geisel School of Medicine at Dartmouth, USA.
⁴² University of California, Irvine, USA.
⁴³ University of Pittsburgh, USA.
⁴⁴ Dalhousie University, USA.
⁴⁵ University of Exeter, USA.
⁴⁶ Harvard Medical School, McLean Hospital, USA.
⁴⁷ National Center for PTSD and Stanford University, USA.
⁴⁸ Maastricht University, USA.
⁴⁹ Reliant Medical Group, OptumCare and Harvard Medical School, USA.
⁵⁰ University of Haifa, USA.
⁵¹ University of California, Los Angeles and University of Arizona, USA. Electronic address: cohenzd@arizona.edu.

PMID: 38086157
DOI: 10.1016/j.brat.2023.104443

Free article

Implementing precision methods in personalizing psychological therapies: Barriers and possible ways forward

Anne-Katharina Deisenhofer et al. Behav Res Ther. 2024 Jan.

Free article

. 2024 Jan:172:104443.

doi: 10.1016/j.brat.2023.104443. Epub 2023 Dec 1.

Authors

Affiliations

¹ University of Trier, Germany. Electronic address: deisenhofer@uni-trier.de.
² University of Sheffield, UK.
³ University of Oxford, UK.
⁴ University of Trier, Germany.
⁵ Yeshiva University, USA.
⁶ The University of Texas at Austin, USA.
⁷ Princeton University, USA.
⁸ Ruhr University Bochum, Germany.
⁹ AmsterdamUMC, Department of Psychiatry, Research Program Amsterdam Public Health and Centre for Urban Mental Health, University of Amsterdam, the Netherlands.
¹⁰ University of Greifswald, Germany.
¹¹ Royal Holloway University of London, UK.
¹² University College London, UK.
¹³ Pennsylvania State University, USA.
¹⁴ University of Louisville, USA.
¹⁵ University of Cambridge, UK.
¹⁶ Leiden University, Institute of Psychology, USA.
¹⁷ University of Pennsylvania, USA.
¹⁸ Radboud University, USA.
¹⁹ University of Miami, USA.
²⁰ University of California, Berkeley, USA.
²¹ Leiden University, USA.
²² University of Cambridge, UK; Philipps University of Marburg, Germany.
²³ Kyoto University, USA.
²⁴ School of Psychology, Trinity College Institute for Neuroscience, And Global Brain Health Institute, Trinity College Dublin, USA.
²⁵ University of Buenos Aires, USA.
²⁶ Emory University, USA.
²⁷ Philipps University of Marburg, Germany.
²⁸ Vanderbilt University, USA.
²⁹ Dartmouth Geisel School of Medicine, USA.
³⁰ MindMed, Inc., Tufts University School of Medicine, USA.
³¹ Trinity College Dublin, USA.
³² Indiana University-Bloomington, USA.
³³ Stony Brook University, USA.
³⁴ Florida International University, USA.
³⁵ Warren Alpert Medical School of Brown University, USA.
³⁶ Harvard Medical School, USA.
³⁷ University of Washington, USA.
³⁸ Osnabrück University, USA.
³⁹ King's College London and South London and Maudsley NHS Foundation Trust, USA.
⁴⁰ Stony Brook University and Feinberg School of Medicine Northwestern University, USA.
⁴¹ National Center for PTSD and Geisel School of Medicine at Dartmouth, USA.
⁴² University of California, Irvine, USA.
⁴³ University of Pittsburgh, USA.
⁴⁴ Dalhousie University, USA.
⁴⁵ University of Exeter, USA.
⁴⁶ Harvard Medical School, McLean Hospital, USA.
⁴⁷ National Center for PTSD and Stanford University, USA.
⁴⁸ Maastricht University, USA.
⁴⁹ Reliant Medical Group, OptumCare and Harvard Medical School, USA.
⁵⁰ University of Haifa, USA.
⁵¹ University of California, Los Angeles and University of Arizona, USA. Electronic address: cohenzd@arizona.edu.

PMID: 38086157
DOI: 10.1016/j.brat.2023.104443

No abstract available

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Conflict of interest statement

Declaration of competing interest Michael Barkham has co-produced outcome measures used in routine outcome monitoring and also jointly published a text on routine outcome monitoring but receives no financial payment for these activities. Christopher G. Beevers has received funding for his research from the National Institutes of Health, Brain and Behavior Foundation, Aiberry Inc., and other private, not-for-profit foundations. He has received income from the Association for Psychological Science for his editorial work and from Orexo, Inc. for serving on a Scientific Advisory Board related to digital therapeutics. Dr. Beevers' financial disclosures have been reviewed and approved by the University of Texas at Austin in accordance with its conflict-of-interest policies. Tim Dalgleish has received payment for consultancy work with Princeton Biopartners, Boehringer Ingelheim and Felix Inc. He delivers paid workshops on psychological therapies. He receives royalties for books on affect and psychological disorders. Nicholas C. Jacobson declares the following conflicts of interest. He has edited a book that includes discussion of this topic from which he receives royalties. Additionally, he has accepted paid speaking invitations from various organizations. Dr. Jacobson confirms that these interests do not influence the research, interpretation, or conclusions presented in this manuscript. Daniel R. Karlin is an employee, officer, and shareholder of MindMed; shareholder and director at Sonara Health; trustee at Trudeau Institute; shareholder and consultant to NightWare; consultant to Otsuka, Tempus, Limitless Ventures, Recovery Delivered, and 4YouandMe. Cheri A. Levinson has a financial interest in BeWell and Awaken Digital Solutions. Lorenzo Lorenzo-Luaces has received consulting fees from Syra Health who had no involvement in the current research. Stephen M. Schueller serves on the Scientific Advisory Board for Headspace for which he receives compensation and has received consulting payments from Boehringer Ingelheim, K Health (Trusst), and Otsuka Pharmaceuticals for unrelated work. Greg J. Siegle receives royalty payments on a patent regarding a vibroacoustic intervention for psychiatric conditions, licensed to Apollo Neurosciences. Wolfgang Lutz and Eva-Lotta Brakemeier initiated and chair the Interest Group "Evidence-Based Personalized Psychotherapy Research (ePePsy)" of the German Psychological Association.

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Implementing precision methods in personalizing psychological therapies: Barriers and possible ways forward

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Implementing precision methods in personalizing psychological therapies: Barriers and possible ways forward

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Conflict of interest statement

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