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Comment
. 2023 Dec 11;41(12):2014-2016.
doi: 10.1016/j.ccell.2023.11.006.

NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms

Stefanie Gerstberger  1 , Karuna Ganesh  2
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NEN in a dish: A patient-derived organoid biobank illuminates potential novel therapeutic opportunities for neuroendocrine neoplasms

Stefanie Gerstberger et al. Cancer Cell. .
Free article

Abstract

Neuroendocrine neoplasms are rare cancers with limited treatment options and preclinical models. In this issue of Cancer Cell, Dayton et al. establish a patient-derived tumor organoid biobank encompassing pulmonary low-grade neuroendocrine tumors (LNETs) and high-grade neuroendocrine carcinomas (LCNECs), identifying novel biomarker-dependent therapeutic vulnerabilities using niche perturbation and drug response assays.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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