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. 2023 Dec 12;24(1):368.
doi: 10.1186/s12882-023-03421-w.

The association of visceral adiposity index with the risk of kidney stone and kidney stone recurrence

Dan Liang #  1   2 , Chang Liu #  3 , Mei Yang  4
Affiliations

The association of visceral adiposity index with the risk of kidney stone and kidney stone recurrence

Dan Liang et al. BMC Nephrol. .

Abstract

Aim: Our aim in this study was primarily to assess the relationship between visceral adiposity index (VAI) and the risk of kidney stones and kidney stone recurrence in US adults.

Methods: We used data from the National Health and Nutrition Examination Survey (NHANES) 2007-2014 for our analysis. VAI was calculated from waist circumference (WC), body mass index (BMI), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-C). Kidney stones and recurrence of kidney stones were obtained from questionnaire interview data. We used multivariate logistic regression analysis to explore the correlation between VAI and the risk of kidney stone and kidney stone recurrence. In addition, we performed subgroup analysis, interaction tests, and restricted cubic spline (RCS) analysis.

Results: A total of 9886 participants were included in this study, with a prevalence of 9.24% for kidney stones and 2.97% for recurrence of kidney stones. The prevalence of kidney stones and kidney stone recurrence increased with higher quartiles of VAI. We observed a significantly positive correlation between VAI and the risk of kidney stone and kidney stone recurrence. Participants with the highest VAI quartiles had a 48% (OR: 1.48, 95%CI: 1.08-2.02) and 52% (OR: 1.52, 95%CI: 0.86-2.71) increased risk of kidney stones and kidney stone recurrence, respectively, compared to participants with the lowest VAI quartiles. Subgroup analysis and interaction tests demonstrated this positive association independent of different subgroup factors.

Conclusion: Visceral fat accumulation may be associated with an increased risk of kidney stones and kidney stone recurrence.

Keywords: Kidney stones; Kidney stones recurrence; NHANES; VAI.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of the sample selection from National Health and Nutrition Examination Survey (NHANES) 2007–2014
Fig. 2
Fig. 2
The restricted cubic spline (RCS) analysis between VAI and the risk of kidney stone and kidney stone recurrence
Fig. 3
Fig. 3
Subgroup analysis for the association between VAI and kidney stones
Fig. 4
Fig. 4
Subgroup analysis for the association between VAI and kidney stone Recurrence
See this image and copyright information in PMC

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