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. 2023 Nov 19:24:100635.
doi: 10.1016/j.ebr.2023.100635. eCollection 2023.

Societal costs and quality of life analysis in patients undergoing resective epilepsy surgery: A one-year follow-up

L Maas  1   2 , J Kellenaers  1 , G van Mastrigt  2 , S M J van Kuijk  3 , M C G Vlooswijk  1   4 , M Hiligsmann  2 , S Klinkenberg  2   5 , L Wagner  6   4 , J Nelissen  1   4 , O E M G Schijns  1   6   4 , H J M Majoie  6   4   5 , K Rijkers  1   6   4
Affiliations

Societal costs and quality of life analysis in patients undergoing resective epilepsy surgery: A one-year follow-up

L Maas et al. Epilepsy Behav Rep. .

Abstract

Although effectiveness of Resective Epilepsy Surgery (RES) for patients with drug-resistant epilepsy (DRE) is widely proven, research on the impact of societal costs (SC) is lacking. The aim of this study is to provide both clinical and economic outcomes of RES by offering an overview of treatment effectiveness as well as SC of RES in a cohort of 30 Dutch DRE patients. This project serves as a pilot project to offer an up-to-date model for larger cost-effectiveness studies. Medical consumption, productivity losses, disease-specific and generic health-related quality of life (QoL), and seizure frequency were assessed before and 3-, 6-, and 12-months post-surgery with validated questionnaires. Linear mixed models, ANOVAs, and logistic regressions were performed. SC for the first year after RES entailed €54,376 and decreased over time. Moreover, 50% of patients experienced a clinically important increase in disease-specific QoL and 53% of patients in generic health-related QoL. Lastly, 73% of patients reached seizure freedom 12 months postoperative. Seizure reduction was correlated with increase in disease-specific QoL. Within one year after surgery, RES leads to reduction in SC and improvements in QoL over time. Future research should encompass longer follow-up periods, larger sample size, and a cost-effectiveness analysis with a comparator.

Keywords: Cost-effectiveness; Drug-resistant epilepsy patients; Epilepsy; Quality of life; Resective epilepsy surgery; Societal costs.

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Conflict of interest statement

Mickaël Hiligsmann has received research grants paid to his institution by Amgen, Radius Health and Angelini Pharma, advisory grant from Pfizer (paid to institution), lecture fees (paid to institution) from IBSA, all outside the current work. All other authors declare no conflicts of interest. This study was not funded.The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Total societal costs per time point, in red (increase in costs) and green (decrease in costs) boxes the differences in costs between time points are illustrated. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
Fig. 2
Fig. 2
Boxplot disease-specific QoL average scores per time point (left) and boxplot generic health-related QoL average scores over time (right).
See this image and copyright information in PMC

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