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. 2023 Oct 27;42(4):557-564.
doi: 10.5937/jomb0-42947.

Red blood cell distribution width (RDW) is a significant predictor of survival in laryngeal cancer patients: Systematic literature review and meta-analysis

Riccardo Nocini  1 , Fabian Sanchis-Gomar  2 , Giuseppe Lippi  3 , Camilla Mattiuzzi  4
Affiliations

Red blood cell distribution width (RDW) is a significant predictor of survival in laryngeal cancer patients: Systematic literature review and meta-analysis

Riccardo Nocini et al. J Med Biochem. .

Abstract
in English, Serbian

Background: This systematic literature review and meta-analysis investigated whether the red blood cell distribution (RDW) may predict survival outcomes in laryngeal cancer patients undergoing curative treatment.

Methods: We conducted an electronic search in Medline and Scopus using the keywords "red blood cell distribution width" OR "RDW" AND "laryngeal cancer" OR "larynx cancer" OR "laryngeal carcinoma" OR "larynx carcinoma," without time or language restrictions (up to February 2023), for identifying studies investigating the prognostic value of RDW in patients with any form of laryngeal cancer and with a primary endpoint that was set as survival rate and/or disease-free survival between 1 and 10 years after curative treatment. The research was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 reporting checklist.

Metode: Izvršili smo elektronsku pretragu u Medline i Scopusu koriste}i ključne reći "širina distribucije crvenih krvnih zrnaca" ILI "RDW" I "rak larinksa" ILI "karcinom larinksa" ILI "karcinom larinksa" ILI "karcinom larinksa", bez vremenskih ili jezičkih ograničenja (do februara 2022. godine), za identifikaciju prognostičkih vrednosti RDW u pacijenata sa bilo kojim oblikom laringealnog kancera i sa primarnom krajnjom tačkom koja je postavljena kao stopa preživljavanja i/ili preživljavanje bez bolesti izme|u 1 i 10 godina nakon kurativnog lečenja. Istraživanje je sprovedeno prema PRISMA (Preferred Reporting Items for Sistematic Revievs and Meta-Analises) kontrolnoj listi za izveštavanje za 2020. godinu.

Rezultati: Digitalna pretraga nam je omogućila da identifikujemo pet studija koje su konačno uključene u na{u objedinjenu analizu (stopa preživljavanja i/ili preživljavanje bez bolesti pokrivali su period izmđu 2,7-8,3 godine). U četiri od pet studija, povećana vrednost RDW kod pacijenata sa karcinomom larinksa koji su bili podvrgnuti hirurškom tretmanu ili tretmanu zračenjem bila je povezana sa lošijim preživljavanjem (opseg odnosa šanse ORs, 2,28-10,44). U objedinjenoj analizi, povećani RDW je dao preko 3 puta veći rizik od umiranja tokom praćenja nakon kurativnog lečenja karcinoma larinksa (OR, 3,37; 95% CI, 1,41-8,10).

Zaključak: RDW zadržava klinički važnu prognostičku vrednost kod pacijenata sa karcinomom larinksa koji su podvrgnuti kurativnom lečenju. Kliničari bi mogli da priznaju ove informacije za korišćenje agresivnije terapije ili postavljanje užeg praćenja kod pacijenata sa rakom larinksa sa povećanim vrednostima RDW.

Keywords: RDW, red blood cell distribution width; anisocytosis; laryngeal cancer, larynx cancer.

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Conflict of interest statement

All the authors declare that they have no conflict of interest in this work.Conflict of Interest: The authors stated that they have no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1. Pooled analysis of studies exploring the predictive role of red blood cell distribution width (RDW) in laryngeal cancer patients undergoing curative therapy. Results are shown as odds ratio (OR) and 95% confidence interval (95% CI).
Figure 2
Figure 2. Funnel plot of studies exploring the predictive role of red blood cell distribution width (RDW) in laryngeal cancer patients undergoing curative therapy. Results are shown as odds ratio (OR).
See this image and copyright information in PMC

References

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