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Review
. 2024 Apr;281(4):1643-1649.
doi: 10.1007/s00405-023-08348-4. Epub 2023 Dec 13.

Application of organoids in otolaryngology: head and neck surgery

Hai Zhu  1 , Siyuan Qu  1 , Yongqin Deng  1 , Mengdan Gong  1 , Yizhen Xiang  1 , Yaoshu Teng  2 , Dong Ye  3
Affiliations
Review

Application of organoids in otolaryngology: head and neck surgery

Hai Zhu et al. Eur Arch Otorhinolaryngol. 2024 Apr.

Abstract

Purpose: The purpose of this review is to systematically summarize the application of organoids in the field of otolaryngology and head and neck surgery. It aims to shed light on the current advancements and future potential of organoid technology in these areas, particularly in addressing challenges like hearing loss, cancer research, and organ regeneration.

Methods: Review of current literature regrading organoids in the field of otolaryngology and head and neck surgery.

Results: The review highlights several advancements in the field. In otology, the development of organoid replacement therapies offers new avenues for treating hearing loss. In nasal science, the creation of specific organoid models aids in studying nasopharyngeal carcinoma and respiratory viruses. In head and neck surgery, innovative approaches for squamous cell carcinoma prediction and thyroid regeneration using organoids have been developed.

Conclusion: Organoid research in otolaryngology-head and neck surgery is still at an early stage. This review underscores the potential of this technology in advancing our understanding and treatment of various conditions, predicting a transformative impact on future medical practices in these fields.

Keywords: 3D tissue model; Organoids; Otolaryngology—head and neck surgery; Stem cells; Tumor prediction model.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The acquisition, construction and application of organoids
Fig. 2
Fig. 2
Organoid construction process
See this image and copyright information in PMC

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