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Randomized Controlled Trial
. 2024 Jan;114(1):68-78.
doi: 10.2105/AJPH.2023.307444.

Preexposure Prophylaxis Uptake Among Spanish-Speaking Transgender Women: A Randomized Controlled Trial in North and South Carolina, 2019-2022

Scott D Rhodes  1 , Jorge Alonzo  1 , Lilli Mann-Jackson  1 , Lucero Refugio Aviles  1 , Amanda E Tanner  1 , Carla A Galindo  1 , Patricia A Bessler  1 , Cari Courtenay-Quirk  1 , Manuel Garcia  1 , Ana D Sucaldito  1 , Benjamin D Smart  1 , Tamar Goldenberg  1 , Beth A Reboussin  1
Affiliations
Randomized Controlled Trial

Preexposure Prophylaxis Uptake Among Spanish-Speaking Transgender Women: A Randomized Controlled Trial in North and South Carolina, 2019-2022

Scott D Rhodes et al. Am J Public Health. 2024 Jan.

Abstract

Objectives. To evaluate Chicas Creando Acceso a la Salud (Girls Creating Access to Health; ChiCAS), a Spanish-language, small-group intervention designed to increase preexposure prophylaxis (PrEP) use, consistent condom use, and medically supervised gender-affirming hormone therapy use among Spanish-speaking transgender Latinas who have sex with men. Methods. Participants were 144 HIV-negative Spanish-speaking transgender Latinas, aged 18 to 59 years, living in North and South Carolina. From July 2019 to July 2021, we screened, recruited, and randomized them to the 2-session ChiCAS intervention or the delayed-intervention waitlist control. Participants completed assessments at baseline and 6-month follow-up. Follow-up retention was 94.4%. Results. At follow-up, relative to control participants, ChiCAS participants reported increased PrEP use (adjusted odds ratio [AOR] = 4.64; 95% confidence interval [CI] = 1.57, 13.7; P < .006). However, ChiCAS participants did not report increased use of condoms or medically supervised gender-affirming hormone therapy. ChiCAS participants reported increases in knowledge of HIV (P < .001), sexually transmitted infections (P < .001), and gender-affirming hormone therapy (P = .01); PrEP awareness (P < .001), knowledge (P < .001), and readiness (P < .001); condom use skills (P < .001); and community attachment (P < .001). Conclusions. The ChiCAS intervention was efficacious in increasing PrEP use among Spanish-speaking, transgender Latinas in this trial. (Am J Public Health. 2024;114(1):68-78. https://doi.org/10.2105/AJPH.2023.307444).

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Figures

FIGURE 1—
FIGURE 1—
Schematic of the Research Design to Test the ChiCAS Intervention for HIV-Negative Spanish-Speaking Transgender Latinas: North and South Carolina, 2019–2022
See this image and copyright information in PMC

References

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