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Comment
. 2023 Dec 12;56(12):2670-2672.
doi: 10.1016/j.immuni.2023.11.013.

Stat5a sobers up inTOXicated T cells

Lara V Donhauser  1 , Dietmar Zehn  2
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Stat5a sobers up inTOXicated T cells

Lara V Donhauser et al. Immunity. .
Free article

Abstract

Exhausted T cells are largely hampered by epigenetically enforced mechanisms that limit their effector potential. In this issue of Immunity, Beltra et al. found that Stat5 can alter these epigenetic profiles when T cells transition from the Tpex precursor stage into differentiated cells. At this stage, enforced Stat5 expression increases the number of intermediate exhausted T cells and induces durable effector cells with superior anti-tumor activity.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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