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Comment
. 2023 Dec 12;56(12):2677-2678.
doi: 10.1016/j.immuni.2023.11.014.

A maelstrom of migrating monocytes drives neurodegeneration

Nicole G Coufal  1 , Michelle L Hermiston  2
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Free article
Comment

A maelstrom of migrating monocytes drives neurodegeneration

Nicole G Coufal et al. Immunity. .
Free article

Abstract

Neurodegeneration is a devastating complication of Langerhans cell histiocytosis (LCH), but it is not clear how it develops. In this issue of Immunity, Wilk et al. demonstrate that circulating BRAFV600E+ myeloid cells damage the blood-brain barrier and infiltrate the brain. Dual inhibition of the MAPK and senescence pathways can block parenchymal injury, providing a potential therapeutic avenue for histiocytic neurodegeneration.

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Conflict of interest statement

Declaration of interests M.L.H. serves on an external advisory board for Sobi Pharmaceuticals.

Comment on

  • Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders.
    Wilk CM, Cathomas F, Török O, Le Berichel J, Park MD, Bigenwald C, Heaton GR, Hamon P, Troncoso L, Scull BP, Dangoor D, Silvin A, Fleischmann R, Belabed M, Lin H, Merad Taouli E, Boettcher S, Li L, Aubry A, Manz MG, Kofler JK, Yue Z, Lira SA, Ginhoux F, Crary JF, McClain KL, Picarsic JL, Russo SJ, Allen CE, Merad M. Wilk CM, et al. Immunity. 2023 Dec 12;56(12):2790-2802.e6. doi: 10.1016/j.immuni.2023.11.011. Immunity. 2023. PMID: 38091952 Free PMC article.

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