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Comment
. 2023 Dec 12;56(12):2679-2681.
doi: 10.1016/j.immuni.2023.11.012.

Cytotoxic Th1 cells mushroom after fungal exposures in Crohn's disease

Martin Stražar  1 , Ramnik J Xavier  2
Affiliations
Free article
Comment

Cytotoxic Th1 cells mushroom after fungal exposures in Crohn's disease

Martin Stražar et al. Immunity. .
Free article

Abstract

Fungi are consistently enriched in inflamed intestines, with elusive effects on host immunity. In a recent issue of Nature Medicine, Martini et al. identify a subset of Th1 cells able to lyse the epithelium, enriched in Crohn's disease patient samples after fungal exposure.

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Conflict of interest statement

Declaration of interests R.J.X is a co-founder of Celsius Therapeutics and Jnana Therapeutics, board director at MoonLake Immunotherapeutics, and consultant to Nestlé.

Comment on

  • Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn's disease.
    Martini GR, Tikhonova E, Rosati E, DeCelie MB, Sievers LK, Tran F, Lessing M, Bergfeld A, Hinz S, Nikolaus S, Kümpers J, Matysiak A, Hofmann P, Saggau C, Schneiders S, Kamps AK, Jacobs G, Lieb W, Maul J, Siegmund B, Seegers B, Hinrichsen H, Oberg HH, Wesch D, Bereswill S, Heimesaat MM, Rupp J, Kniemeyer O, Brakhage AA, Brunke S, Hube B, Aden K, Franke A, Iliev ID, Scheffold A, Schreiber S, Bacher P. Martini GR, et al. Nat Med. 2023 Oct;29(10):2602-2614. doi: 10.1038/s41591-023-02556-5. Epub 2023 Sep 25. Nat Med. 2023. PMID: 37749331 Free PMC article.

References