Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Dec 13;17(1):182.
doi: 10.1186/s13065-023-01070-6.

Glycosides from the leaves of Fraxinus Hubeiensis

Xin-Yi Liu #  1 , Hong-Xia Tang #  1 , Wen-Bing Sheng  1 , Qu-Jing Luo  1 , Lin-Xi Mao  1 , Yu-Pei Yang  1 , Xiao-Zhou Guo  1 , Qing-Lai Wu  2 , Yu-Qing Jian  1 , Wei Wang  3 , Xu-Dong Zhou  4
Affiliations

Glycosides from the leaves of Fraxinus Hubeiensis

Xin-Yi Liu et al. BMC Chem. .

Abstract

Fraxinus hubeiensis is a plant endemic to China and widely used as folk medicine to treat various diseases. However, its chemical constituents have never been reported sufficiently. Thus, the primary objective of this study was to investigate the phytochemical constituents and biological activities of F. hubeiensis leaves. Hence, combined column chromatographic and spectroscopic techniques were used to identify and characterize the secondary metabolites such as a pair of 3-keto-glycoside epimers (1) and (2), along with five known compounds (3 ~ 7). The results of α-glucosidase inhibitory activity exhibited that 1 and 2 had moderate activity with IC50 values of 359.50 and 468.43 µM, respectively, compared to a positive control acarbose with the IC50 value of 164.08 µM. However, Compounds 1-6 were shown to be inactive against the tested microbes.

Keywords: 3-keto-glycoside; Chiral separation; Fraxinus hubeiensis; Spectroscopic analysis; α-glucosidase inhibitory.

PubMed Disclaimer

Conflict of interest statement

The authors declare that there are no competing interests to others.

Figures

Fig. 1
Fig. 1
Chemical structures of 1–7 isolated from F. hubeiensis
Fig. 2
Fig. 2
Key 1 H-1 H COSY and HMBC correlations of compounds 1 and 2
See this image and copyright information in PMC

References

    1. Qu SZ, Xiang QB, Su PL. A new specie of the genus Fraxinus Linn. From Hubei province [J] J Nanjing Forestry Univ (Natural Sci Edition) 1979;21:146–8.
    1. Zeng XB, Wang JC, Wu WX. Fraxinus hupehensis—A new specie of the genus Fraxinus Linn. [J] For Sci Technol. 1979;12:6–7.
    1. Chinese Pharmacopoeia Commission . Pharmacopoeia of the people’s Republic of China [M] Beijing: China Medical Science Press; 2020.
    1. Cheng JR, Zhou MQ. The distribution status and conservation strategy of Fraxinus Hupehensis germplasm resources [J] J Yangtze Univ (Natural Sci Edition) 2016;13(09):7–9.
    1. Zhao CN, Yao ZL, Yang D, Ke J, Wu QL, Li JK, Zhou XD. Chemical constituents from Fraxinus hupehensis and their antifungal and herbicidal activities [J]. Biomolecules, 2020, 10(1). - PMC - PubMed

LinkOut - more resources