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. 2024 Apr;23(4):1243-1252.
doi: 10.1111/jocd.16125. Epub 2023 Dec 13.

A survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean Dermatologists

Nark Kyoung Rho  1   2 , Kwang Ho Han  3 , Minah Cho  4 , Hei Sung Kim  4
Affiliations

A survey on the cosmetic use of injectable polynucleotide: The pattern of practice among Korean Dermatologists

Nark Kyoung Rho et al. J Cosmet Dermatol. 2024 Apr.

Abstract

Background: Skin boosters denote injectables that promote global improvement of the skin which includes skin texture, elasticity, hydration, and overall appearance. Polynucleotide (PN) products have become popular, but there is surprisingly little guidance on their use. We aimed to maximize the safety and efficacy of injectable PN by providing information on their pattern of practice among board-certified dermatologists.

Methods: A total of 235 Korean board-certified dermatologists familiar with skin boosters participated in a survey which questioned the participant's years of practice, selection of skin boosters in one's clinic, and range of lasers and light sources as well as skin care devices that are available. For those who use PN, one was asked to check all its aesthetic indications, mode of delivery, injection depth, treatment interval as well as options for combined therapy.

Results: Seventy-one percent of the survey participants had at least 5 years of professional experience as a board-certified dermatologist, and among the different skin boosters, 88% replied that they practiced PN injection. The top six indications for PN were fine lines on the cheek followed by infraorbital fine lines, periorbital fine lines, uneven skin texture, dry skin, and fine lines on the forehead. Many opted for a 33G needle and the serial puncture technique targeting the dermis. A total of three sessions of PN injection spaced 4 weeks apart is most often recommended. 79 percent of PN users blended PN injection with lasers and light therapy with the most popular being radiofrequency (non-invasive, needle RF) and high-intensity focused ultrasound (HIFU).

Conclusion: PN is a skin booster which is widely practiced among Korean dermatologists. According to our survey, the best indication of PN is facial fine lines, and as such PN injection is often repeated and combined with a variety of non-surgical rejuvenation procedures. We hope our data help dermatologists better understand and utilize PN injection.

Keywords: Korean dermatologists; polynucleotide; skin boosters; survey.

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References

REFERENCES

    1. Arora G, Arora S, Sadoughifar R, Batra N. Biorevitalization of the skin with skin boosters: concepts, variables, and limitations. J Cosmet Dermatol. 2021;20(8):2458‐2462.
    1. Squadrito F, Bitto A, Irrera N, et al. Pharmacological activity and clinical use of PDRN. Front Pharmacol. 2017;8:224.
    1. Aawrish K, Guobao W, Feng Z, et al. Polydeoxyribonucleotide: a promising skin anti‐aging agent. Chin J Plastic Reconstruct Surg. 2022;4(4):187‐193.
    1. Galeano M, Pallio G, Irrera N, et al. Polydeoxyribonucleotide: a promising biological platform to accelerate impaired skin wound healing. Pharmaceuticals (Basel). 2021;14(11):1103.
    1. Park KY, Seok J, Rho NK, Kim BJ, Kim MN. Long‐chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients. Dermatol Ther. 2016;29(1):37‐40.

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