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Editorial
. 2023 Oct 23;8(10):1283-1284.
doi: 10.1016/j.jacbts.2023.08.007. eCollection 2023 Oct.

On Your MARCKS…Get Set…Go: The Race to Explore Myristoylation in HF Is Underway

Benjamin P Keepers  1 , Brian C Jensen  2   3   4
Affiliations
Editorial

On Your MARCKS…Get Set…Go: The Race to Explore Myristoylation in HF Is Underway

Benjamin P Keepers et al. JACC Basic Transl Sci. .
No abstract available

Keywords: N-myristoylation; cardiac remodeling; gene therapy; heart failure; posttranslational modifications.

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Conflict of interest statement

The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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Graphical abstract
See this image and copyright information in PMC

Comment on

  • doi: 10.1016/j.jacbts.2023.06.006

References

    1. Tomita Y., Anzai F., Misaka T., et al. Targeting N-myristoylation through NMT2 prevents cardiac hypertrophy and heart failure. J Am Coll Cardiol Basic Trans Science. 2023;8(10):1263–1282. - PMC - PubMed
    1. Hartwig J.H., Thelen M., Rosen A., Janmey P.A., Nairn A.C., Aderem A. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature. 1992;356(6370):618–622. - PubMed
    1. Wright M.H., Heal W.P., Mann D.J., Tate E.W. Protein myristoylation in health and disease. J Chem Biol. 2009;3(1):19–35. - PMC - PubMed
    1. Duronio R.J., Towler D.A., Heuckeroth R.O., Gordon J.I. Disruption of the yeast N-myristoyl transferase gene causes recessive lethality. Science. 1989;243(4892):796–800. - PubMed
    1. Gao J., Shao K., Chen X., et al. The involvement of post-translational modifications in cardiovascular pathologies: Focus on SUMOylation, neddylation, succinylation, and prenylation. J Mol Cell Cardiol. 2020;138:49–58. - PubMed

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