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. 2024 May 31;16(2):146-150.
doi: 10.4274/jcrpe.galenos.2023.2023-7-7. Epub 2023 Dec 15.

Serum Ghrelin and Glucagon-like Peptide 1 Levels in Children with Prader-Willi and Bardet-Biedl Syndromes

Doğa Türkkahraman  1 , Suat Tekin  1 , Merve Güllü  1 , Güzin Aykal  2
Affiliations

Serum Ghrelin and Glucagon-like Peptide 1 Levels in Children with Prader-Willi and Bardet-Biedl Syndromes

Doğa Türkkahraman et al. J Clin Res Pediatr Endocrinol. .

Abstract

Objective: Prader-Willi syndrome (PWS) and Bardet-Biedl syndrome (BBS) are causes of pediatric syndromic obesity. We aimed to investigate a possible role for ghrelin and glucagon-like peptide-1 (GLP-1) in the pathophysiology of PWS and BBS.

Methods: The study included 12 children with PWS, 12 children with BBS, 13 pediatric obese controls (OC) and 12 pediatric lean controls (LC). Fasting serum ghrelin and GLP-1 levels were measured by ELISA.

Results: In the PWS group, no significant difference was detected for median ghrelin levels when compared with OC and LC, which were 0.96 (0.69-1.15), 0.92 (0.72-1.20) and 1.13 (0.84-1.29) ng/mL, respectively. Similarly, there was no difference in PWS median GLP-1 levels when compared with OC and LC; 1.86 (1.5-2.94), 2.24 (1.62-2.78) and 2.06 (1.8-3.41) ng/mL, respectively. In the BBS group, there was no difference in median ghrelin levels when compared with OC and LC; 1.05 (0.87-1.51), 0.92 (0.72-1.20) and 1.13 (0.84-1.29) ng/mL, respectively. Neither was there a significant difference in median GLP-1 levels; 2.46 (1.91-4.17), 2.24 (1.62-2.78) and 2.06 (1.8-3.41) ng/mL for BBS, OC and LC, respectively.

Conclusion: There were no differences in median fasting ghrelin or GLP-1 levels when comparing patients with PWS and BBS with obese or lean peers. However, similar studies with larger series are needed.

Keywords: BBS; GLP-1; PWS; ghrelin.

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Box-plot presentation of serum ghrelin (ng/mL) and GLP-1 (ng/mL) levels in subjects with PWS and BBS, and in OC and LC. The lower and upper limits of the boxes represent 25th and 75th percentiles, and middle lines in each box represent 50th percentile, while the bottom and top end of the whiskers represent the minimum and maximum values, respectively. Dots represent the outlier data PWS: Prader-Willi syndrome, BBS: Bardet-Biedl syndrome, GLP-1: glucagon-like peptide-1, OC: obese control, LC: lean control
See this image and copyright information in PMC

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