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Randomized Controlled Trial
. 2023 Dec 15;18(12):e0295175.
doi: 10.1371/journal.pone.0295175. eCollection 2023.

Effects of a mindfulness-based intervention and a health self-management programme on psychological well-being in older adults with subjective cognitive decline: Secondary analyses from the SCD-Well randomised clinical trial

Marco Schlosser  1   2 , Harriet Demnitz-King  2 , Thorsten Barnhofer  3 , Fabienne Collette  4   5 , Julie Gonneaud  6 , Gaël Chételat  6 , Frank Jessen  7   8   9 , Matthias Kliegel  1 , Olga M Klimecki  10   11 , Antoine Lutz  12 , Natalie L Marchant  2 ; Medit-Ageing Research Group
Affiliations
Randomized Controlled Trial

Effects of a mindfulness-based intervention and a health self-management programme on psychological well-being in older adults with subjective cognitive decline: Secondary analyses from the SCD-Well randomised clinical trial

Marco Schlosser et al. PLoS One. .

Abstract

Objectives: Older adults with subjective cognitive decline (SCD) recruited from memory clinics have an increased risk of developing dementia and regularly experience reduced psychological well-being related to memory concerns and fear of dementia. Research on improving well-being in SCD is limited and lacks non-pharmacological approaches. We investigated whether mindfulness-based and health education interventions can enhance well-being in SCD.

Methods: The SCD-Well trial (ClinicalTrials.gov: NCT03005652) randomised 147 older adults with SCD to an 8-week caring mindfulness-based approach for seniors (CMBAS) or an active comparator (health self-management programme [HSMP]). Well-being was assessed at baseline, post-intervention, and 6-month post-randomisation using the Psychological Well-being Scale (PWBS), the World Health Organisation's Quality of Life (QoL) Assessment psychological subscale, and composites capturing meditation-based well-being dimensions of awareness, connection, and insight. Mixed effects models were used to assess between- and within-group differences in change.

Results: CMBAS was superior to HSMP on changes in connection at post-intervention. Within both groups, PWBS total scores, psychological QoL, and composite scores did not increase. Exploratory analyses indicated increases in PWBS autonomy at post-intervention in both groups.

Conclusion: Two non-pharmacological interventions were associated with only limited effects on psychological well-being in SCD. Longer intervention studies with waitlist/retest control groups are needed to assess if our findings reflect intervention brevity and/or minimal base rate changes in well-being.

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Conflict of interest statement

GC, FC, OMK, AL, and NLM have received research support from the EU’s Horizon 2020 research and innovation programme (grant agreement number 667696). GC has received research support from Inserm, Fondation d’entreprise MMA des Entrepreneurs du Futur, Fondation Alzheimer, Programme Hospitalier de Recherche Clinique, Région Normandie, Association France Alzheimer et maladies apparentées and Fondation Vaincre Alzheimer (all to Inserm), GC and AL have received research support and personal fees from Fondation d’entreprise MMA des Entrepreneurs du Futur. All other authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Longitudinal changes in meditation-based well-being composite scores (awareness, connection, insight), Psychological Well-being Scale (PWBS) total scores, and WHOQOL-BREF Psychological Quality of Life (QoL) by group (CMBAS = Caring Mindfulness-based Approach for Seniors, HSMP = Health Self-Management Programme).
The figure displays observed standardised means and SEs (error bars = 1 SE) based on all available data.
See this image and copyright information in PMC

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