Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1987 Feb 20;235(4791):877-80.
doi: 10.1126/science.3810169.

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

D Goldgaber, M I Lerman, O W McBride, U Saffiotti, D C Gajdusek
Comparative Study

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

D Goldgaber et al. Science. .

Abstract

Four clones were isolated from an adult human brain complementary DNA library with an oligonucleotide probe corresponding to the first 20 amino acids of the beta peptide of brain amyloid from Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids, including the known amino acid sequence of this polypeptide. The 3.5-kilobase messenger RNA was detected in mammalian brains and human thymus. The gene is highly conserved in evolution and has been mapped to human chromosome 21.

PubMed Disclaimer

Publication types

Associated data

LinkOut - more resources