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. 2024 Jul;166(1):163-172.
doi: 10.1002/ijgo.15304. Epub 2023 Dec 16.

Physical energies for the management of genitourinary syndrome of menopause: An overview of a systematic review and network meta-analysis

Ayane Cristine Alves Sarmento  1 , Juliana Dantas de Araújo Santos Camargo  1 , Cijara Leonice de Freitas  1 , Kleyton Santos Medeiros  1   2 , Ana Paula Ferreira Costa  1   2 , Ana Katherine Gonçalves  1   3
Affiliations

Physical energies for the management of genitourinary syndrome of menopause: An overview of a systematic review and network meta-analysis

Ayane Cristine Alves Sarmento et al. Int J Gynaecol Obstet. 2024 Jul.

Abstract

Background: Energy-based devices (laser and radiofrequency) have been used to treat genitourinary syndrome of menopause (GSM).

Objectives: To evaluate the efficacy and safety of physical energy use in managing GSM symptoms.

Search strategy: Five databases were searched from inception to December 2022. Language restrictions were not imposed.

Selection criteria: We included all Cochrane and non-Cochrane systematic reviews with or without meta-analyses that described postmenopausal women with symptoms of GSM treated with physical energy.

Data collection and analysis: We performed a network meta-analysis using frequentist methods to calculate standardized mean differences (SMDs) and their corresponding 95% confidence intervals (CIs). Methodological and reporting quality were assessed using the Assessment of Multiple Systematic Reviews (AMSTAR 2).

Main results: Nine reviews were included in the overview, six of which were meta-analyses. Four randomized controlled trials, representing 218 participants and nine different study arms, met the criteria for inclusion in our component network meta-analysis. Confidence in review findings was low in six reviews and critically low in three. Our network meta-analysis results showed that premarin (SMD 2.60, 95% CI 7.76-3.43), conjugated estrogens (SMD 2.13, 95% CI 1.34-2.91), carbon dioxide laser (SMD 1.71, 95% CI 1.10-2.31), promestriene (SMD 1.41, 95% CI 0.59-2.24), and vaginal lubricant (SMD 1.37, 95% CI 0.54-2.20) were more effective than sham for reducing sexual dysfunction, with a consequent increase in Female Sexual Function Index (FSFI). Two studies showed a high risk of bias, owing to a lack of blinding.

Conclusion: Several gaps in the use of physical energy for managing GSM still need to be addressed. The small number of blind clinical trials made the results fragile.

Keywords: atrophy; laser therapy; menopause; network meta‐analysis; overview; radiofrequency therapy.

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References

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