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. 2024 Jul;54(7):692-701.
doi: 10.1007/s00595-023-02779-6. Epub 2023 Dec 16.

Clinical utility of the carcinoembryonic antigen level in patients with stage III colon cancer after surgery and adjuvant chemotherapy

Shohei Udagawa  1 , Hiroki Osumi  1 , Ryotaro Kozuki  2 , Akira Ooki  1 , Takeru Wakatsuki  1 , Nozomi Kurihara  3 , Toshiki Mukai  2 , Tomohiro Yamaguchi  2 , Takashi Akiyoshi  2 , Yosuke Fukunaga  2 , Kensei Yamaguchi  1 , Eiji Shinozaki  4
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Clinical utility of the carcinoembryonic antigen level in patients with stage III colon cancer after surgery and adjuvant chemotherapy

Shohei Udagawa et al. Surg Today. 2024 Jul.

Abstract

Purpose: The association between perioperative and post-adjuvant carcinoembryonic antigen (CEA) levels and recurrence and prognosis remains unclear. We aimed to evaluate whether perioperative CEA levels are an integral component of the assessment of recurrence and prognosis of patients with stage III colon cancer (CC).

Methods: This retrospective study was conducted at the Cancer Institute Hospital of the Japanese Foundation for Cancer Research from 2005 to 2013. We enrolled patients with stage III CC who underwent complete resection of a primary tumor and received adjuvant chemotherapy. We analyzed the association between perioperative and post-adjuvant CEA levels and recurrence-free survival (RFS) and overall survival (OS).

Results: A total of 564 consecutive patients were included in the analysis. The RFS and OS of patients with high postoperative CEA levels were significantly worse than those of patients with normal postoperative CEA levels. In the multivariate analysis, high postoperative CEA levels were associated with shorter RFS and OS. The number of risk factors, postoperative CEA levels, and T/N-stage all had a cumulative effect on RFS and OS.

Conclusions: High postoperative CEA levels and the number of risk factors are associated with recurrence and worse prognosis for patients with stage III CC.

Keywords: Carcinoembryonic antigen; Colonic neoplasms; Postoperative period; Recurrence; Risk.

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