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. 2024 Apr;35(4):719-725.
doi: 10.1007/s10552-023-01830-8. Epub 2023 Dec 16.

Awareness of the causal association between human papillomavirus and anal cancer among US adults

Joseph Atarere  1 , Onyema Chido-Amajuoyi  2 , Henry Onyeaka  3 , Ogheneyoma Akpoviroro  4 , Comfort Adewunmi  5 , Ange Ahoussougbemey Mele  6 , Chilota O Faith  7 , Somtochi Nwani  8 , Priyanka Kanth  9
Affiliations

Awareness of the causal association between human papillomavirus and anal cancer among US adults

Joseph Atarere et al. Cancer Causes Control. 2024 Apr.

Abstract

Purpose: The incidence of anal cancer is on the rise in the US, especially among high-risk groups. This study examined the prevalence and determinants of awareness of the causal relationship between HPV and anal cancer among US adults.

Methods: Study data was obtained from the 2017 to 2020 iterations of the Health Information National Trends Survey. The prevalence of awareness that HPV causes anal cancer was estimated among HINTS respondents who were aware of HPV in general. Survey weights were used to provide estimates representative of the adult US population. Multivariable logistic regressions were used to examine the associations between awareness that HPV causes anal cancer and cancer-related behaviors/perceptions and sociodemographic characteristics of respondents.

Results: Two thousand six hundred and eighty four (27.2%) of the study population were aware that HPV caused anal cancer. Those of gay sexual orientation were more aware than heterosexuals [OR 2.27; 95% CI (1.24, 4.14)]. Compared to respondents with a high school diploma or less, individuals with some college education [OR 1.38; 95% CI (1.03, 1.85)] and those with at least a college degree [OR 1.52; 95% CI (1.17, 1.98)] were more likely to be aware. Participants who had positive cancer information seeking behavior were more aware of the HPV-anal cancer link compared to those who did not [OR 1.57; 95% CI (1.30, 1.89)].

Conclusion: Population-level awareness that HPV causes anal cancer remains critically low in the US. Sexual orientation, level of education and cancer information seeking behavior are associated with increased awareness of the causal relationship between HPV and anal cancer. Efforts should be directed toward addressing the awareness gap among individuals with lower education levels and promoting curiosity-driven information seeking behaviors.

Keywords: Anal cancer; Cancer awareness; Human papillomavirus; Sexual and gender minorities.

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