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. 2024 Jan;65(1):100485.
doi: 10.1016/j.jlr.2023.100485. Epub 2023 Dec 14.

From NAFLD to MASLD: updated naming and diagnosis criteria for fatty liver disease

Mary E Rinella  1 , Silvia Sookoian  2
Affiliations

From NAFLD to MASLD: updated naming and diagnosis criteria for fatty liver disease

Mary E Rinella et al. J Lipid Res. 2024 Jan.
No abstract available

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Conflict of interest statement

Conflict of interest M. E. R. provides scientific consulting for Boehringer Ingelheim, Cytodyn, Histoindex, Intercept, GSK, Madrigal, Novo Nordisk, and Takeda over the past 24 months. No speakers’ bureaus or stock ownership reported. S.S. declares no conflicts of interest with the contents of this article.

Figures

Fig. 1
Fig. 1
SLD was chosen as the overarching term to encompass the various causes of steatosis. NAFLD will now be called MASLD, which includes patients with hepatic steatosis and at least one of five cardiometabolic risk factors (adult and pediatric can be found elsewhere (14, 15, 16)). MASH replaces NASH in referring to metabolic dysfunction-associated steatohepatitis. The term steatohepatitis was considered an important pathophysiological concept that should be retained. A new category, MetALD, describes individuals with MASLD who consume more than 140 g/week of alcohol for women and 210 g/week for men. If additional factors contributing to steatosis are discovered, then this aligns with a combined etiology. When it comes to alcohol, the condition is referred to as MetALD or ALD, depending on the severity of alcohol consumption. If no overt cardiometabolic criteria are present, other causes should be ruled out. If none are identified, this is called cryptogenic SLD. Depending on clinical judgment, it may also be considered possible MASLD and would benefit from periodic reassessment on a case-by-case basis. ∗Weekly intake 140–350 g female, 210–420 g male. ∗∗e.g.: lysosomal acid lipase deficiency (LALD), Wilson disease, hypobetalipoproteinemia, and inborn errors of metabolism. ∗∗∗Hepatitis C virus, malnutrition, celiac disease, and human immunodeficiency virus.
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References

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