A Novel Comprehensive Therapeutic Approach to the Challenges of Chronic Wounds: A Brief Review and Clinical Experience Report

Abstract

Following the clinical perspective and concept that a healthy body will not develop chronic wounds, the central approach for the treatment described here is based on an understanding of how the body transforms the wound microenvironment from a non-healing to a healing state. As part of a comprehensive treatment regimen that includes OCM™ (complete matrix), wound preparation, and skin protectant formulations, the OCM contains components for complete wound healing by attending to the individual needs required to promote the closure of each unique chronic wound. During application of the comprehensive treatment regimen in independent investigator-led trials, the total wound percentage average reduction over the first 4 weeks of treatment was 60% across multiple wound types; median time to total wound closure was 6.9 weeks. Safety testing of the OCM formulation shows no potential allergenicity, no potential sensitization, and no known product-related adverse events. Clinical trials evaluating the OCM formulation as part of the comprehensive treatment regimen of multiple wound types are underway. Results of clinical trials and real-world experiences will expand current knowledge of the wound-healing potential of this novel product.

Keywords: Chronic wound; Complete matrix; Comprehensive wound management; OCM; Refractory wound; Wound healing.

Fig. 1

A Total wound closure and B mean time to total wound closure with combination therapy and from the US Wound Registry [55]. DFU diabetic foot ulcer, PrU pressure ulcer, VLU venous leg ulcer

Fig. 2

PAR of the wound at week 4 of combination therapy. DFU diabetic foot ulcer, PAR percent area reduction, PrU pressure ulcer, VLU venous leg ulcer

Fig. 3

Case study of total closure of a chronic venous stasis ulcer after 5 weeks of combination therapy