AC is supported by the National Institute for Health and Care Research (NIHR) Oxford Cognitive Health Clinical Research Facility, by an NIHR Research Professorship (grant RP-2017-08-ST2-006), by the NIHR Oxford and Thames Valley Applied Research Collaboration, by the NIHR Oxford Health Biomedical Research Centre (grant NIHR203316), and by the Wellcome Trust. AC has also received research, educational, and consultancy fees from the Italian Network for Paediatric Trials, the CARIPLO Foundation, Lundbeck, and Angelini Pharma. AC is the Chief Investigator of one trial about seltorexant in adolescent depression, sponsored by Janssen. The views expressed here are those of the authors and not necessarily those of the UK National Health Service, the NIHR, or the UK Department of Health. GS reports research grants paid to her institution by the Swiss National Science Foundation, the European Commission, and the Wellcome Trust. AA declares no competing interests.