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. 2023 Nov 17;15(11):e48939.
doi: 10.7759/cureus.48939. eCollection 2023 Nov.

Serum Interleukin-19 Levels in Acne Vulgaris Patients of Varying Clinical Severity in Erbil City

Hazha M Mohammed  1 , Dindar S Qurtas  2 , Alan D Meran  2
Affiliations

Serum Interleukin-19 Levels in Acne Vulgaris Patients of Varying Clinical Severity in Erbil City

Hazha M Mohammed et al. Cureus. .

Abstract

Background Acne vulgaris (AV) is a common multifactorial disorder affecting the pilosebaceous units. Research has shown that inflammation plays a crucial role in the pathogenesis of AV, including both inflammatory and non-inflammatory acne. Several studies have linked proinflammatory cytokines to AV; however, only a few have explored the correlation between interleukin-19 (IL-19) and AV. Our aim is to estimate the level of IL-19 in patients with AV compared to matched controls and to investigate the role of IL-19 in the pathogenesis of acne. Materials and methods This prospective cross-sectional case and control study includes 80 patients and 40 matched controls. Patients were divided into mild (20), moderate (40), and severe (20) groups based on their global acne score severity index. Detailed history and complete general and dermatological examinations were taken from each patient. Furthermore, 5 ml of blood was taken from all participants to assess the level of IL-19. Results IL-19 levels were significantly higher in patients with AV compared to matched controls. Furthermore, IL-19 concentrations were found to be proportional to the severity of acne, with the highest levels detected in patients with severe AV (p-value <0.005). Conclusion IL-19 levels in AV were significantly higher than in matched control. The difference was proportional to its severity. This might indicate IL-19 as an inflammatory marker and could potentially be related to AV.

Keywords: acne vulgaris; erbil; global acne score index; il-19; inflammation.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Comparison of IL-19 concentration between patients and control group.
IL-19: Interleukin-19.
Figure 2
Figure 2. IL-19 concentration in control group and acne patients of varying severity.
IL-19: Interleukin-19.
See this image and copyright information in PMC

References

    1. Acne vulgaris: diagnosis and treatment. Ogé LK, Broussard A, Marshall MD. https://www.aafp.org/pubs/afp/issues/2019/1015/p475.html. Am Fam Physician. 2019;100:475–484. - PubMed
    1. Topical, biological and clinical challenges in the management of patients with Acne vulgaris. Al-Hammadi A, Al-Ismaily A, Al-Ali S, Ramadurai R, Jain R, McKinley-Grant L, Mughal TI. Sultan Qaboos Univ Med J. 2016;16:0. - PMC - PubMed
    1. Propionibacterium acnes and Acne Vulgaris: new insights from the integration of population genetic, multi-omic, biochemical and host-microbe studies. McLaughlin J, Watterson S, Layton AM, Bjourson AJ, Barnard E, McDowell A. Microorganisms. 2019;7:128. - PMC - PubMed
    1. Differences of microbiomes found in non-inflammatory and inflammatory lesions of acne vulgaris. Jusuf NK, Putra IB, Sari L. Clin Cosmet Investig Dermatol. 2020;13:773–780. - PMC - PubMed
    1. Does inflammatory acne result from imbalance in the keratinocyte innate immune response? Grange PA, Weill B, Dupin N, Batteux F. Microbes Infect. 2010;12:1085–1090. - PubMed

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