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. 2023 Oct 10;16(2):62-86.
doi: 10.21500/20112084.6486. eCollection 2023 Jul-Dec.

Basal Forebrain Modulation of Olfactory Coding In Vivo

Juan Pablo Venegas  1 , Marcela Navarrete  1 , Laura Orellana-Garcia  1 , Marcelo Rojas  1 , Felipe Avello-Duarte  1 , Alexia Nunez-Parra  1
Affiliations

Basal Forebrain Modulation of Olfactory Coding In Vivo

Juan Pablo Venegas et al. Int J Psychol Res (Medellin). .

Abstract
in English, Spanish

Sensory perception is one of the most fundamental brain functions, allowing individuals to properly interact and adapt to a constantly changing environment. This process requires the integration of bottom-up and topdown neuronal activity, which is centrally mediated by the basal forebrain, a brain region that has been linked to a series of cognitive processes such as attention and alertness. Here, we review the latest research using optogenetic approaches in rodents and in vivo electrophysiological recordings that are shedding light on the role of this region, in regulating olfactory processing and decisionmaking. Moreover, we summarize evidence highlighting the anatomical and physiological differences in the basal forebrain of individuals with autism spectrum disorder, which could underpin the sensory perception abnormalities they exhibit, and propose this research line as a potential opportunity to understand the neurobiological basis of this disorder.

La percepción sensorial es una de las funciones cerebrales más fundamentales, permitiendo a los individuos interactuar de manera apropiada con el entorno y adaptarse a un ambiente en constante cambio. Este proceso requiere la integración de la actividad neuronal ascendente y descendente, que es mediada por el cerebro basal (BF), una región cerebral que ha sido asociada a una serie de procesos cognitivos, como estados de atención y alerta.En este trabajo revisamos las últimas investigaciones que han utilizado optogenética y registros electrofisiológicos in vivo que han iluminado el rol del BF en el procesamiento olfatorio y la toma de decisiones. Además, resumimos la literatura que destaca las alteraciones fisiológicas y anatómicas del BF de individuos con trastornos del espectro autista, que podrían subyacer las anormalidades en la percepción que presentan, y proponemos esta línea de investigación como una posible oportunidad para entender las bases neurobiológicas de este trastorno.

Keywords: GABA; acetylcholine; electrophysiological recording.; neuromodulation; olfactory bulb; optogenetic; sensory processing.

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Conflict of interest statement

Conflict of interests: The authors have declared that there is no conflict of interest.

Figures

Figure 1
Figure 1. Olfactory System and Neuromodulation of Basal Forebrain onto Olfactory Bulb
See this image and copyright information in PMC

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