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. 2023 Sep 24;11(12):7921-7929.
doi: 10.1002/fsn3.3709. eCollection 2023 Dec.

The effect of different prebiotics on intestinal probiotics in newly diagnosed diabetic patients

Yu Zhang  1 , Lidan Yang  2 , Yitian Wu  3 , He He  2 , Yuping Zeng  2 , Zhenmei An  1 , Weiguo Jia  4
Affiliations

The effect of different prebiotics on intestinal probiotics in newly diagnosed diabetic patients

Yu Zhang et al. Food Sci Nutr. .

Abstract

Prebiotics exert favorable effects on the host through interactions with probiotics, and their beneficial impacts have been extensively validated across various chronic ailments, including diabetes. This study presents findings from a case-control investigation involving 10 individuals with type 2 diabetes mellitus (T2DM) and 10 healthy counterparts. Fresh stool specimens were collected from all participants. Following a 24-h fermentation period in mediums containing xylitol and mannitol, the observed increase in Lactobacillus abundance within the case group exceeded that of the control group. Similarly, in mediums containing soluble starch, choline, and L-carnitine, the augmentation of Bifidobacterium within the case group surpassed that of the controls. Notably, a statistically significant divergence in sugar degradation rate emerged between the case and control groups, specifically in the medium harboring lactulose and isomalto-oligosaccharides. Remarkably, the degradation rate of lactulose exhibited a positive correlation with the expansion of Bifidobacterium (R 2 = .147, p = .037). Likewise, the degradation rate of isomalto-oligosaccharides demonstrated a positive correlation with Bifidobacterium proliferation (R 2 = .165, p = .041). In conclusion, prebiotics like xylitol and mannitol exhibit the capacity to enhance intestinal probiotic populations in individuals newly diagnosed with diabetes. The modifications in the intestinal flora homeostasis of diabetic patients may be evidenced by alterations in the degradation rate of specific prebiotic substrates.

Keywords: degradation rate; diabetes; intestinal flora; prebiotics; probiotics.

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Conflict of interest statement

Yu Zhang, Lidan Yang, Yitian Wu, He He, Yuping Zeng, Zhenmei An, and Weiguo Jia declares that they have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
The increase in Lactobacillus in different prebiotic media. A, Mannite; B, Xylitol; C, Mucin; D, Sodium carboxymethyl starch; E, Glucose; F, Fructo‐oligos; G, Galacto‐oligosaccharides; I, Isomalto‐oligosaccharide; L, Lactulose; M, Mannan‐oligosaccharide; R, Raffinose; S, Soluble starch; SDZ, Soluble starch+ Choline+L‐carnitine; U, Inulin; X, Xylo‐oligosaccharides; YDZ, Y + Choline+L‐carnitine.*p < .05.
FIGURE 2
FIGURE 2
The increase in Bifidobacterium in media containing different prebiotics. A, Mannite; B, Xylitol; C, Mucin; D, Sodium carboxymethyl starch; E, Glucose; F, Fructo‐oligos; G, Galacto‐oligosaccharides; I, Isomalto‐oligosaccharide; L, Lactulose; M, Mannan‐oligosaccharide; R, Raffinose; S, Soluble starch; SDZ, Soluble starch+ Choline+L‐carnitine; U, Inulin; X, Xylo‐oligosaccharides; YDZ, Y + Choline+L‐carnitine.*p < .05.
FIGURE 3
FIGURE 3
Degradation rate of carbohydrate prebiotics. D, Sodium carboxymethyl starch; E, Glucose; F, Fructo‐oligos; G, Galacto‐oligosaccharides; I, Isomalto‐oligosaccharide; L, Lactulose; M, Mannan‐oligosaccharide; R‐Raffinose; S, Soluble starch; U, Inulin; X, Xylo‐oligosaccharides. *p < .05.
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